Sandra Diaz-Twine (born July 30, 1974) is an American television personality who became known for her appearances on the reality game show Survivor. She won the first two seasons she appeared on, Survivor: Pearl Islands and Survivor: Heroes vs. Villains, making her the show's first two-time winner. She returned for Survivor's 34th season, Survivor: Game Changers, where she was the 6th person voted out. Along with fellow Survivor contestant Rob Mariano, she was a non-competing mentor on the show's 39th season Survivor: Island of the Idols, and subsequently competed on the show's 40th season, Survivor: Winners at War, where she was the 7th person voted out and only player to leave the game at the Edge of Extinction. She also competed for a fifth time on Survivor on the Blood V Water edition of the Australian Survivor with her daughter Nina, which aired in 2022.

Diaz-Twine is regarded among fans as one of the greatest players on the show.

Diaz-Twine was born in Stamford, Connecticut and for a time served in the United States Army as a chemical repair specialist and later an office administrator. She lives in Fayetteville, North Carolina with her husband Marcus, a career soldier, and her two children, while working as a secretary for a law firm. On the February 12, 2026, episode of the Rob Has a Podcast podcast hosted by fellow Survivor player Rob Cesternino, she mentioned that she and her husband are retired.

Diaz-Twine seemed like an early target for her lack of physical strength and inability to swim, but her knowledge of the Spanish language and her resourcefulness, which helped their tribe Drake gather much needed resources from local traders at the start of the game, put her in good standing with the majority of her tribe. She eventually formed an alliance with Rupert Boneham, Christa Hastie, Trish Dunn, and Jonny Fairplay. Diaz-Twine was the first person to sit out of a challenge and the first to raid on Morgan's camp as part of the reward, where she not only took their tarp, but sabotaged their shelter. When Drake lost the fourth and fifth immunity challenges, the alliance voted out the minority alliance's Burton Roberts and Michelle Tesauro. When Drake lost the sixth immunity challenge, the originally-targeted Shawn Cohen was saved when Diaz-Twine turned the alliance against Dunn for instigating an attempted blindside of Boneham.

With the Drake and Morgan tribes even at five members each, they were shocked when the six contestants who had been previously voted out came back into the game as a third tribe, in a turn of events called the "Outcast Twist." When the tribe of Outcasts competed against the Drake and Morgan tribes and subsequently won the immunity challenge, two of the Outcasts were allowed to return to the game. At the same time, both Drake and Morgan were forced to vote out a tribe member. In a game-changing move, Diaz-Twine, Boneham, and Hastie, unsure about whether to send home Cohen, the last minority alliance member left, or Fairplay, who betrayed them previously together with Dunn, asked them to publicly campaign for their spot. The alliance eventually eliminated Cohen, and received Roberts as a replacement from The Outcasts.

As the tribes merged into Balboa at 5–5, the Drake tribe, with the help of outcast Roberts, was able to sway Morgan outcast Lillian "Lil" Morris to vote with them, controlling the game and subsequently voting out Morgan leaders Andrew Savage and Ryan Opray. However, the game took a major shift when old Drake members Fairplay and Roberts aligned themselves with Morris, and recruited the remaining Morgan members Tijuana "Ti" Bradley and Darrah Johnson. This new alliance successfully targeted Boneham and he was blindsided.

At the Final Seven, it seemed that Diaz-Twine and Hastie were doomed by this newly created alliance, but Diaz-Twine swayed Bradley and Johnson by spying on Roberts and Fairplay to expose their intentions to eliminate the Morgan girls after getting rid of Diaz-Twine and Hastie. However, when Roberts and Fairplay learned of this impending mutiny, they regained the trust of Diaz-Twine and Hastie (with the help of Fairplay’s infamous "dead grandmother" lie) to successfully blindside Bradley. Soon after that, they were betrayed once again when Roberts and Dalton switched sides and Hastie was voted out next.

At the Final Five, Johnson was the next target of Roberts and Fairplay, but Morris started to have suspicions about her alliance (which would prove true eventually). Roberts made a potentially fatal error by inviting Dalton on his reward trip, leaving the three women, including an angered Morris, together back at camp, sparking a last minute scramble to break the bond between the two guys, eventually voting out Roberts for the second time in the game.