The Sanquhar Declaration was a speech read by Michael Cameron in the presence of his brother, the Covenanter leader Richard Cameron, accompanied by twenty armed men in the public square of Sanquhar, Scotland, in 1680, disavowing allegiance to Charles II and the government of Scotland, in the name of "true Protestant and Presbyterian interest", opposition to government interference in religious affairs.

This symbolic demonstration, essentially a declaration of war, was among the first of a series of events that led to the Glorious Revolution and the end of the reign of the House of Stuart.