Santini Cycling is a cycling clothes brand of the Italian clothing production company Santini Maglificio Sportivo. Established in 1965 in Bergamo, Santini developed from Pietro Santini's enthusiasm for cycling. Items are made in Italy.

Santini began in 1965 when Pietro Santini founded the company under the name Santini Maglificio Sportivo.

After the initial years, where production was dedicated to general wool garments, the company moved towards sportswear, and cycling apparel, in particular.

The 1970s marked a shift for Santini Cycling. The company began to experiment materials like Lycra for cycling shorts, gradually replacing the traditional wool with synthetics. Santini introduced synthetic, anti-bacterial paddings, gradually replacing the traditional chamois.

1977 is the year of the first international cycling team sponsored by Santini, named Peugeot/Esso-Michelin. The beginning of sponsorships Peugeot/Esso-Michelin was the first real international team sponsorship for Santini.

Santini made use of Polyamide in the manufacture of jerseys. In 1979 Santini started producing coloured shorts: before that time this garment was traditionally black.

At the beginning of the 1980’s the sublimatic printing process was invented and Santini was one of the first producers to introduce it in the world of professional cycling. As cycling teams needed a way to include more sponsor logos on their apparel, the traditional embroidery process proved both time-consuming and impractical.

1984 saw the launch of the Team La Vie Claire jersey. The team La Vie Claire colours were based on the artwork of Piet Mondrian. Manufactured by Santini.