Satkhira District (Bengali: সাতক্ষীরা জেলা; lit. 'Seven cucumbers') is a district in southwestern Bangladesh and is part of Khulna Division. It lies along the border with West Bengal, India. It is on the bank of the Arpangachhia River. The largest city and headquarter of this district is Satkhira.

The district consists of two municipalities, seven upazilas, 79 union parishads, 8 thanas (police stations) and 1,436 villages.

The upazilas are:

The two municipalities are Satkhira and Kalaroa.

Satkhira District has an area of 3,817 square kilometres (1,474 sq mi). It is bordered to the north by Jessore District, on the south by the Bay of Bengal, to the east by Khulna District, and to the west by North 24 Parganas and South 24 Parganas districts of West Bengal, India.

The annual average maximum temperature reaches 35.5 °C (95.9 °F); minimum temperature is 12.5 °C (54.5 °F). The annual rainfall is 1710 mm (67 in).

The main rivers are the Kopotakhi river across Dorgapur union of Assasuni Upazila, Morichap River, Kholpetua River, Betna River, Raimangal River, Hariabhanga river, Ichamati River, Betrabati River and Kalindi-Jamuna River.

Tropical savanna climates have a monthly mean temperature above 18 °C (64 °F) in every month of the year and typically a pronounced dry season, with the driest month having precipitation less than 60mm (2.36 in) of precipitation. The Köppen Climate Classification subtype for this climate is "Aw" (tropical savanna climate).