Scream is an American anthology slasher television series developed by Jill Blotevogel, Dan Dworkin and Jay Beattie for MTV and Brett Matthews for VH1. It is based on the titular film series created by Kevin Williamson. The series is produced by Dimension Television and MTV Production Development, and was formerly filmed in Louisiana, in locations such as Baton Rouge and New Orleans. Blotevogel and Jaime Paglia originally served as showrunners during the first season before being replaced by Michael Gans and Richard Register in the second season, because of creative differences. The first two seasons were situated in the fictional town of Lakewood, where a string of murders took place. At the center of those murders was Emma Duval (played by Willa Fitzgerald), a teenage girl who is somehow tied to the town's dark past.

The series premiered on MTV on June 30, 2015, and concluded its first season on September 1, 2015. The series was officially picked up for a second season in July 2015. After its second season concluded, a two-hour Halloween special aired in October 2016.

In October 2016, MTV renewed the series for a third season. In April 2017, MTV announced that they were rebooting the series with the third season, with a new cast and setting. As part of the reboot process, it was revealed that Brett Matthews would be serving as the main showrunner. In addition, Queen Latifah, Shakim Compere and Yaneley Arty would be added as executive producers for the series under Flavor Unit Entertainment. RJ Cyler, C. J. Wallace, Tyga, Keke Palmer, Jessica Sula, Giorgia Whigham, Giullian Yao Gioiello and Tyler Posey starred in the rebooted third season. In June 2019, it was announced that the series would be moving to VH1 ahead of the premiere of the third and final season. The season, subtitled Resurrection, premiered on July 8, 2019.

Scream is a serialized anthology series that follows a group of teenagers being stalked and targeted by a masked serial killer.

The first two seasons, set in a fictional version of the town of Lakewood, Colorado, follow the story of Emma Duval, a teenage girl, who is linked to the horrific events of the town's past. As the killer's main obsession starts to take a hold after a brutal murder in the present day, Emma finds herself in the center of imminent peril. With both family and friends in danger, she sets out to uncover the town's secrets and unmask the identity of the Lakewood Slasher.

The third season follows the story of Deion Elliot, a local football star in Atlanta, who is tormented by the events of his tragic past. As Ghostface uses his darkest secrets against him and continues with a killing spree, Deion not only stands to lose his future, but also, the lives of his friends and family members, who might end up being potential victims of the notorious and infamous killer.

In June 2012, it was reported that MTV was in the early stages of developing a weekly television series based on the Scream film franchise. In April 2013, The Hollywood Reporter confirmed that MTV had greenlit the pilot episode, with Wes Craven in talks to direct. In July 2013, it was reported that Jay Beattie and Dan Dworkin had officially boarded the project to write the pilot script and in April 2014, it was reported by TVLine that the series would be penned by Jill Blotevogel. In August 2014, the series announced its cast as well as the director of the pilot episode, Jamie Travis. The series was originally planned to debut in mid-2014, however, this was changed to summer 2015.

An official promotional picture of the series' re-imagined mask was revealed in early June 2015. Initially, Craven expressed his approval of the redesign and hinted at its origins and possible plot significance. However, Craven was later critical about the network's decision to abandon the Ghostface mask in the television series. Later, it was reported that there were preliminary discussions about incorporating the mask in the first two seasons. However, the initial plans were scrapped in favor of a new mask, due to creative reasons. Sometime after the announcement of the reboot, MTV made a deal with Fun World, in order to acquire the licensing rights to the Ghostface mask for the series.