Scream is an American slasher franchise that includes six films (and a seventh in active development), a television series, merchandise, and games. The first four films were directed by Wes Craven. The series was created by Kevin Williamson, who wrote the first two films and the fourth, and will return to write and direct the seventh film. Ehren Kruger wrote the third. The fifth and sixth installments were directed by Matt Bettinelli-Olpin and Tyler Gillett, with Guy Busick and James Vanderbilt serving as writers and Williamson returning as executive producer. Dimension Films produced the first four films. Spyglass Media Group took over the rights from the fifth film on with Paramount Pictures distributing. The film series has grossed over US$910 million at the global box office.

Neve Campbell, Courteney Cox, David Arquette, and Roger L. Jackson (who voices the various Ghostface killers) starred in the first five films, and will return for the seventh. Cox and Jackson reprised their roles for the sixth and are the only cast members to feature in all films to date, with Cox also being the only actress to appear in six consecutive films of a horror franchise. Hayden Panettiere stars in the fourth and sixth films, while Melissa Barrera, Jenna Ortega, Mason Gooding, and Jasmin Savoy Brown star in the fifth and sixth, with Gooding and Brown also reprising their roles in the seventh. Jamie Kennedy and Liev Schreiber feature in the first three films, Skeet Ulrich stars in the first and cameos in the fifth and sixth installments, Marley Shelton appears in the fourth and fifth, and Jack Quaid stars in the fifth and cameos in the sixth. Additionally, Heather Matarazzo makes cameo appearances in the third and fifth films, as does Nancy O'Dell in the second, third and fourth. Having appeared in the iconic opening scene of the first film and on its poster, Drew Barrymore is strongly associated with the franchise. The series has also featured many notable actors making single-film appearances in supporting cast roles or as cameos.

Scream (1996), Scream 2 (1997), Scream (2022), and Scream VI (2023) received high praise from critics. Scream 3 (2000) received a more mixed response, as did Scream 4 (2011), Craven's final film; both were later reappraised and the fourth film was generally seen as a return to form for the series. Commercially, the first three films and the fifth and sixth were high performers at the box office, while Scream 4 had a disappointing domestic run. The film series has also been the recipient of several awards and nominations, including winning Best Movie twice at the MTV Awards (for Scream in 1996 and Scream VI in 2023).

The first four films follow Sidney Prescott and her struggle against a succession of murderers who adopt the guise of Ghostface to stalk and kill their victims, the killers often motivated by revenge, jealousy, and seeking notoriety. Sidney receives support from town policeman Dewey Riley, tabloid reporter Gale Weathers, and film-geeks Randy Meeks and Kirby Reed, along with various other friends, romantic partners, and acquaintances that change as the series progresses. The fifth and sixth films follow Samantha Carpenter and her sister, Tara, who are targeted due to their connection to the original killers. Together with their friends Mindy and Chad Meeks-Martin (niece and nephew of Randy Meeks) and some of the original survivors (including Sidney, Gale, Dewey, and Kirby), they must contend with new Ghostface killers.

The first film, Scream, was released on December 20, 1996, and became the highest-grossing slasher film in the world until the release of Halloween (2018). The second entry, Scream 2, was released less than a year later on December 12, 1997. The third installment, Scream 3, was released on February 4, 2000, and was originally the concluding chapter of the series. Eleven years later, the franchise was revived with a fourth installment, Scream 4, which was released on April 15, 2011. An anthology television series Scream, which followed new characters and settings and is not canon to the films, aired for three seasons from 2015 to 2016 on MTV and on VH1 in 2019. A fifth installment in the film series was released on January 14, 2022, directed by Bettinelli-Olpin and Gillett. Busick and Vanderbilt wrote the screenplay, and original creator Williamson returned as an executive producer. It is the first installment in the film series to not be directed by Wes Craven, who died in 2015. A sixth installment, Scream VI, was released on March 10, 2023, developed by the same directors and screenwriters as the fifth film.

Williamson's original script for the first film was bought by Miramax and developed under the Dimension Films label. Craven recruited composer Marco Beltrami to score the film. Williamson was unable to write Scream 3 due to his commitment to other projects. Ehren Kruger replaced him as screenwriter. Kruger also provided uncredited rewrites for Scream 4. Craven ran into conflicts with the Motion Picture Association of America over the series and was forced to reduce the violence in Scream 3 due to the Columbine High School massacre resulting in increased focus on violence in the media. Scream became notable for its use of established and recognizable actors, which was uncommon for slasher films at the time.

The first film has been credited with revitalizing the horror genre in the late 1990s by combining a traditional slasher film with humor, characters aware of horror film cliches and a clever plot. It was one of the highest-grossing films of 1996 and became the highest-grossing slasher film in the world, an honor it held until it was surpassed by 2018's Halloween. Its success was matched by Scream 2, which not only broke box-office records of the time but was also considered superior to the original by some critics. Scream 3 fared worse than its predecessors critically, with many reviewers commenting that it had become the type of horror film it originally parodied in Scream and Scream 2, while others praised it for successfully completing the film trilogy. The movie and its themes were re-evaluated in the wake of the MeToo movement and it underwent a positive reappraisal in the years since its release. Scream 4 also received mixed reviews, with criticism mainly aimed at its use of horror film cliches, although many considered it an improvement over its predecessor. Like the third film, it was critically reappraised years after its release. Both films, especially Scream 4 and its killers' motives, are now widely seen as being ahead of their time. The fifth and sixth entries received mostly positive reviews. Collider said the franchise worked so well because at heart it is really a mystery series.

The film series began with Scream, premiering on December 18, 1996, at the AMC Avco theater in Westwood, California and was generally released on December 20, 1996. Based on a screenplay by screenwriter Kevin Williamson and directed by Wes Craven, creator of the A Nightmare on Elm Street franchise, Scream offered a self-referential approach to horror by featuring a cast of characters aware of the conventions/clichés of the horror film genre and able to use them to survive. The film focuses on teenager Sidney Prescott as she comes under attack from a mysterious character dubbed Ghostface while dealing with the anniversary of her mother's murder. The film went on to be a financial success and received considerable critical acclaim for its deconstruction of the horror genre. It is credited with revitalizing the horror genre in the mid 90s and inspiring an array of imitators. It was particularly notable for its casting of established and popular actors and actresses which was previously uncommon in horror films.