A self-replicating machine is a type of autonomous robot that is capable of reproducing itself autonomously using raw materials found in the environment, thus exhibiting self-replication in a way analogous to that found in nature. The concept of self-replicating machines has been advanced and examined by Homer Jacobson, Edward F. Moore, Freeman Dyson, John von Neumann, Konrad Zuse and in more recent times by K. Eric Drexler in his book on nanotechnology, Engines of Creation (coining the term clanking replicator for such machines) and by Robert Freitas and Ralph Merkle in their review Kinematic Self-Replicating Machines which provided the first comprehensive analysis of the entire replicator design space. The future development of such technology is an integral part of several plans involving the mining of moons and asteroid belts for ore and other materials, the creation of lunar factories, and even the construction of solar power satellites in space. The von Neumann probe is one theoretical example of such a machine. Von Neumann also worked on what he called the universal constructor, a self-replicating machine that would be able to evolve and which he formalized in a cellular automata environment. Notably, Von Neumann's Self-Reproducing Automata scheme posited that open-ended evolution requires inherited information to be copied and passed to offspring separately from the self-replicating machine, an insight that preceded the discovery of the structure of the DNA molecule by Watson and Crick and how it is separately translated and replicated in the cell.

A self-replicating machine is an artificial self-replicating system that relies on conventional large-scale technology and automation. The concept, first proposed by Von Neumann no later than the 1940s, has attracted a range of different approaches involving various types of technology. Certain idiosyncratic terms are occasionally found in the literature. For example, the term clanking replicator was once used by Drexler to distinguish macroscale replicating systems from the microscopic nanorobots or "assemblers" that nanotechnology may make possible, but the term is informal and is rarely used by others in popular or technical discussions. Replicators have also been called "von Neumann machines" after John von Neumann, who first rigorously studied the idea. However, the term "von Neumann machine" is less specific and also refers to a completely unrelated computer architecture that von Neumann proposed and so its use is discouraged where accuracy is important. Von Neumann used the term universal constructor to describe such self-replicating machines.

Historians of machine tools, even before the numerical control era, sometimes figuratively said that machine tools were a unique class of machines because they have the ability to "reproduce themselves" by copying all of their parts. Implicit in these discussions is that a human would direct the cutting processes (later planning and programming the machines), and would then assemble the parts. The same is true for RepRaps, which are another class of machines sometimes mentioned in reference to such non-autonomous "self-replication". Such discussions refer to collections of machine tools, and such collections have an ability to reproduce their own parts which is finite and low for one machine, and ascends to nearly 100% with collections of only about a dozen similarly made, but uniquely functioning machines, establishing what authors Frietas and Merkle refer to as matter or material closure. Energy closure is the next most difficult dimension to close, and control the most difficult, noting that there are no other dimensions to the problem. In contrast, machines that are truly autonomously self-replicating (like biological machines) are the main subject discussed here, and would have closure in each of the three dimensions.

The general concept of artificial machines capable of producing copies of themselves dates back at least several hundred years. An early reference is an anecdote regarding the philosopher René Descartes, who suggested to Queen Christina of Sweden that the human body could be regarded as a machine; she responded by pointing to a clock and ordering "see to it that it reproduces offspring." Several other variations on this anecdotal response also exist. Samuel Butler proposed in his 1872 novel Erewhon that machines were already capable of reproducing themselves but it was man who made them do so, and added that "machines which reproduce machinery do not reproduce machines after their own kind". In George Eliot's 1879 book Impressions of Theophrastus Such, a series of essays that she wrote in the character of a fictional scholar named Theophrastus, the essay "Shadows of the Coming Race" speculated about self-replicating machines, with Theophrastus asking "how do I know that they may not be ultimately made to carry, or may not in themselves evolve, conditions of self-supply, self-repair, and reproduction".

In 1802 William Paley formulated the first known teleological argument depicting machines producing other machines, suggesting that the question of who originally made a watch was rendered moot if it were demonstrated that the watch was able to manufacture a copy of itself. Scientific study of self-reproducing machines was anticipated by John Bernal as early as 1929 and by mathematicians such as Stephen Kleene who began developing recursion theory in the 1930s. Much of this latter work was motivated by interest in information processing and algorithms rather than physical implementation of such a system, however. In the course of the 1950s, suggestions of several increasingly simple mechanical systems capable of self-reproduction were made — notably by Lionel Penrose.

A detailed conceptual proposal for a self-replicating machine was first put forward by mathematician John von Neumann in lectures delivered in 1948 and 1949, when he proposed a kinematic model of self-reproducing automata as a thought experiment. Von Neumann's concept of a physical self-replicating machine was dealt with only abstractly, with the hypothetical machine using a "sea" or stockroom of spare parts as its source of raw materials. The machine had a program stored on a memory tape that instructed it to retrieve parts from this "sea" using a manipulator, assemble them into a copy of itself, and then transfer the contents of its memory tape into the new duplicate. The machine was envisioned as consisting of as few as eight different types of components: four logic elements for sending and receiving stimuli and four mechanical elements for providing structural support and mobility. Although qualitatively sound, von Neumann was evidently dissatisfied with this self-replicating machine model due to the difficulty of analyzing it with mathematical precision. He went on to instead develop an even more abstract model self-replicator based on cellular automata. His original kinematic concept remained obscure until it was popularized in a 1955 issue of Scientific American.

Von Neumann's goal for his self-reproducing automata theory, as specified in his lectures at the University of Illinois in 1949, was to design a machine whose complexity could grow automatically akin to biological organisms under natural selection. He asked what is the threshold of complexity that must be crossed for machines to be able to evolve. His answer was to design an abstract machine which, when run, would replicate itself. Notably, his design implies that open-ended evolution requires inherited information to be copied and passed to offspring separately from the self-replicating machine, an insight that preceded the discovery of the structure of the DNA molecule by Watson and Crick and how it is separately translated and replicated in the cell.

In 1956 mathematician Edward F. Moore proposed the first known suggestion for a practical real-world self-replicating machine, also published in Scientific American. Moore's "artificial living plants" were proposed as machines able to use air, water and soil as sources of raw materials and to draw its energy from sunlight via a solar battery or a steam engine. He chose the seashore as an initial habitat for such machines, giving them easy access to the chemicals in seawater, and suggested that later generations of the machine could be designed to float freely on the ocean's surface as self-replicating factory barges or to be placed in barren desert terrain that was otherwise useless for industrial purposes. The self-replicators would be "harvested" for their component parts, to be used by humanity in other non-replicating machines.