Sempringham Priory was a priory in Lincolnshire, England, located in the medieval hamlet of Sempringham, to the northwest of Pointon. Today, all that remains of the priory is a marking on the ground where the walls stood and a square, which are identifiable only in aerial photos of the vicinity. However, the parish church of St Andrew's, built around 1100 AD, is witness to the priory standing alone in a field away from the main road.

The priory was built by Gilbert of Sempringham, the only English saint to have founded a monastic order. The priory's religious accentuation as an important religious pilgrimage site began when St Gilbert established the Gilbertine Order in 1131 by inducting "seven maidens" who were his pupils. Alexander, Bishop of Lincoln, helped in establishing the religious buildings to the north of St Andrew's Church as a protected area.

St Gilbert died at Sempringham in 1189 and was buried in the priory church. He was canonised on 13 October 1202, for the many miracles noted at his tomb in the priory. His name is prefixed to the Sempringham Priory, which is known as "St Gilbert Sempringham Priory," and is a centre of pilgrimage.

The priory, which functioned as a dual community made up of canons and nuns, was dissolved in 1538. The Clinton family, who took possession of the priory, demolished it completely without leaving any trace of it on the ground. They built a mansion from the building material they extracted from the demolished structure.

Sempringham Priory was spread over an area of 80 acres (0.32 km²) of undulating topography located below the ruins of a major Tudor house skirting the Lincolnshire Fens, which is limestone country. The land of the priory was used for cultivation. It was not known as a former monastery until some archaeological excavations conducted in 1939 by the Heritage Trust of Lincolnshire revealed a layout of the buried presence of the medieval monastery and the housing complex surrounded by gardens. The priory measured 350 feet (110 m) lengthwise, and was inferred to have had within its space buildings for monks and nuns built around the 12th century. At the time of its demolition during the reign of Henry VIII, it was said to be the size of Westminster Abbey.

The Order of Sempringham originated in 1131. In or about that year, Gilbert of Sempringham left the household of Alexander, Bishop of Lincoln, and returned to serve the parish church of Sempringham, of which he was rector. He found there seven maidens, who had learned the way of holiness from him as children, and longed to live a strict religious life. Gilbert, having inherited lands and possessions in Sempringham from his father, resolved to give such wealth as he had for the use of those maidens.

With the help and advice of Alexander, he set up buildings and a cloister for them against the north wall of the church, which stood on his own land at Sempringham. He gave them a rule of life, enjoining upon them chastity, humility, obedience, and charity. Their daily necessities were passed to them through a window by some girls chosen by Gilbert from among his people. His friends warned him that his nuns ought not to speak with secular women, who by their gossip might rekindle in them an interest in the world which they had renounced. On the advice of William, Abbot of Rievaulx, he decided to yield to the request of the serving maids, who begged that they, too, might have a dress and rule of life. Soon afterwards, he took men as lay brothers to work on the land, giving them, too, a uniform and rules.

The little community grew in numbers, and amongst its earliest benefactors was Brian of Pointon. In 1139, Gilbert accepted three carucates of land in Sempringham from Gilbert of Ghent, his feudal lord. His first building had proved too small, and Sempringham Priory, with its double church, cloisters and buildings, was erected on the new site given by Gilbert of Ghent, not far from the parish church, and dedicated to the Virgin. Because of his gift, Gilbert of Ghent was held to be the founder.