Sergey Brin and his then-wife, Anne Wojcicki, established the Brin Wojcicki Foundation. The foundation focuses on various philanthropic areas, including education, health, and addressing global poverty.

Brin has made significant contributions to Parkinson's disease research, driven by his own family history of the condition. The foundation has supported various research initiatives aimed at understanding and treating the disease.

The Brin Wojcicki Foundation has provided substantial funding to Khan Academy, an online education platform, to support its mission of providing free education to anyone, anywhere.

Through the foundation, Brin has supported research into personalized medicine, aiming to develop treatments tailored to individual genetic profiles and characteristics.

The foundation supports various organizations working to alleviate global poverty through initiatives focused on education, healthcare, and economic development.