Sidereus Nuncius (usually Sidereal Messenger, also Starry Messenger or Sidereal Message) is a short astronomical treatise (or pamphlet) published in Neo-Latin by Galileo Galilei on March 13, 1610. It was the first published scientific work based on observations made through a telescope, and it contains the results of Galileo's early observations of the imperfect and mountainous Moon, of hundreds of stars not visible to the naked eye in the Milky Way and in certain constellations, and of the Medicean Stars (Galilean moons) that appeared to be circling Jupiter.

The Latin word nuncius was typically used during this time period to denote messenger; however, it was also (though less frequently) rendered as message. Though the title Sidereus Nuncius is usually translated into English as Sidereal Messenger, many of Galileo's early drafts of the book and later related writings indicate that the intended purpose of the book was "simply to report the news about recent developments in astronomy, not to pass himself off solemnly as an ambassador from heaven."

The first telescopes appeared in the Netherlands in 1608, when Middelburg spectacle-maker Hans Lippershey tried to obtain a patent on one. By 1609 Galileo had learned of this and built his own improved version. He was not the first person to aim the new invention at the night sky but his was the first published study of celestial bodies using one. One of Galileo's first telescopes had 8x to 10x linear magnification and was made out of lenses that he had ground himself. This was increased to 20x linear magnification in the improved telescope he used to make the observations in Sidereus Nuncius.

Sidereus Nuncius contains more than seventy drawings and diagrams of the Moon, certain constellations such as Orion, the Pleiades, and Taurus, and the Medicean Stars of Jupiter. Galileo's text also includes descriptions, explanations, and theories of his observations.

In observing the Moon, Galileo saw that the line separating lunar day from night (the terminator) was smooth where it crossed the darker regions of the Moon but quite irregular where it crossed the brighter areas. From this he deduced that the darker regions are flat, low-lying areas, and the brighter regions rough and mountainous. Basing his estimate on the distance of sunlit mountaintops from the terminator, he judged, quite accurately, that the lunar mountains were at least four miles high. Galileo's engravings of the lunar surface provided a new form of visual representation, besides shaping the field of selenography, the study of physical features on the Moon.

Galileo reported that he saw at least ten times more stars through the telescope than are visible to the naked eye, and he published star charts of the belt of Orion and the star cluster Pleiades showing some of the newly observed stars. With the naked eye observers could see only six stars in the Pleiades; through his telescope, however, Galileo was capable of seeing thirty-five – almost six times as many. When he turned his telescope on Orion, he was capable of seeing eighty stars, rather than the previously observed nine – almost nine times more. In Sidereus Nuncius, Galileo revised and reproduced these two star groups by distinguishing between the stars seen without the telescope and those seen with it. Also, when he observed some of the "nebulous" stars in the Ptolemaic star catalogue, he saw that rather than being cloudy, they were made of many small stars. From this he deduced that the nebulae and the Milky Way were "congeries of innumerable stars grouped together in clusters" too small and distant to be resolved into individual stars by the naked eye.

In the last part of Sidereus Nuncius, Galileo reported his discovery of four objects that appeared to form a straight line of stars near Jupiter. On the first night he detected a line of three little stars close to Jupiter parallel to the ecliptic; the following nights brought different arrangements and another star into his view, totalling four stars around Jupiter. Throughout the text, Galileo gave illustrations of the relative positions of Jupiter and its apparent companion stars as they appeared nightly from late January through early March 1610. That they changed their positions relative to Jupiter from night to night and yet always appeared in the same straight line near it, persuaded Galileo that they were orbiting Jupiter. On January 11 after four nights of observation he wrote:

In his drawings, Galileo used an open circle to represent Jupiter and asterisks to represent the four stars. He made this distinction to show that there was in fact a difference between these two types of celestial bodies. It is important to note that Galileo used the terms planet and star interchangeably, and "both words were correct usage within the prevailing Aristotelian terminology."