Silvermane (Silvio Manfredi) is a supervillain appearing in American comic books published by Marvel Comics. A notorious crime boss and prominent figure in the Maggia, a fictional organized crime syndicate, he is usually depicted as an adversary of the superhero Spider-Man and the father of Joseph Manfredi. Silvermane later became a cyborg in an attempt to extend his lifespan.

The character has made appearances in several forms of media outside of comics, including animated series and video games.

Silvermane first appeared in The Amazing Spider-Man #73, and was created by Stan Lee and John Buscema.

The character's original storyline was about a mysterious stone tablet coveted by several villains. The "Tablet Saga" proved popular, although artist John Romita Sr. said that it was not originally intended as an arc, stating "We never even thought up Silvermane until the seventh issue [of the story arc], let alone a 'socko' ending."

Silvio Manfredi, nicknamed "Silvermane" for his near-white hair, is a professional criminal originally from Corleone, Sicily, Italy, that started his criminal career as a racketeer in the Maggia, eventually forming his own crime family and becoming a powerful Maggia Don.

In his first appearance, an elderly Silvermane forces Curt Connors to make a potion from an ancient clay tablet to grant himself immortality. However, the serum instead causes him to rapidly de-age and eventually fade from existence. Silvermane eventually reappeared, revealing that he had mystically aged to his forties. He started a new career and again quickly rose through the Maggia's ranks until he regained control of his family, the sought to form an alliance with Hydra, determined to take over the world as their leader, the Supreme Hydra. He was defeated by Daredevil, Nick Fury, and S.H.I.E.L.D. Silvermane reappeared in New York in an attempt to unite all of New York's gangs under his leadership and take over the criminal underworld, but his plans were complicated by the Green Goblin, who opposed him. During a confrontation between the Goblin, Silvermane and Spider-Man, Silvermane fell from a great height but survived.

Silvermane has worked with many super-villains, such as Hammerhead, and he has also been known to be a rival of the Kingpin, even once trying to assassinate the crime lord while he was suffering from amnesia. His former partner, Dominic Tyrone, assumed the identity of the Rapier and sought vengeance against Silvermane for betraying him by attempting to take his life. A flashback one-shot focused heavily on Silvermane's lifetime of corruption and crime, going back to his early career in Italy. The framework was reporter Ben Urich investigating the background of the Maggia. He learned that Silvermane was a legendary criminal figure for decades; mothers would even warn their children to behave or "One-Eye" would get them.

In his old age, Silvermane's injuries caused his youth serum to wear off, rendering him an invalid. Though bedridden, he continued to run his criminal empire until Dagger nearly killed him. Silvermane attempted to prolong his life by transforming himself into a cyborg. Kingpin gained control of his cyborg body until Dagger restored his life energy to him. His cyborg body was badly damaged by the first Jack O'Lantern during a gang war between Hammerhead and the Kingpin. Silvermane used a remote-controlled android doppelganger to battle Spider-Man. This was part of an attempt to boost the power of his remaining organic parts by harvesting new ones from Spider-Man's body. He attempted to drain his nemesis's radioactive blood to power a new, much stronger cyborg body. Silvermane also confronted Deathlok and the Punisher while setting up a major drug operation outside a grammar school. Even though he is no longer human, he has continued to remain active in the Maggia.