Smoke inhalation is the breathing in of harmful fumes (produced as by-products of combusting substances) through the respiratory tract. This can cause smoke inhalation injury (a kind of acute inhalation injury) which is damage to the respiratory tract caused by chemical or heat exposure, as well as possible systemic toxicity after smoke inhalation. Smoke inhalation can occur from fires of various sources such as residential, vehicle, and wildfires. Morbidity and mortality rates in fire victims with burns are increased in those with smoke inhalation injury.

Victims of smoke inhalation injury can present with cough, difficulty breathing, low oxygen saturation, smoke debris or burns on the face. Smoke inhalation injury can affect the upper respiratory tract (above the larynx), usually due to heat exposure, or the lower respiratory tract (below the larynx), usually due to exposure to toxic fumes.

Initial treatment includes taking the victim away from the fire and smoke, giving 100% oxygen at a high flow through a face mask (non-rebreather if available), and checking the victim for injuries to the body. Treatment for smoke inhalation injury is largely supportive, with varying degrees of consensus on benefits of specific treatments.

The U.S. Fire Administration reported almost 1.3 million fires in 2019 causing 3,704 deaths and almost 17,000 injuries. Residential fires were found to be most often cooking related and resulted in the highest number of deaths when compared to other fire types such as vehicle and outdoor fires.

It has been found that men have higher rates of fire-related death and injury than women do, and that African American and American Indian men have higher rates of fire-related death and injury than other ethnic and racial groups. The age group with the highest rate of death from smoke inhalation is people over 85, while the age group with the highest injury rate is people of ages 50–54. Some reports also show increased rates of death and injury in children, due to their lower physical and mental capabilities.

In 2019, the overall U.S. national fire death rate was 10.7 people per million population and the injury rate was 50.6 people per million population. According to the U.S. Fire Administration, the deaths in the United States that were caused by a fire fluctuated over the past 10 years. The administration recorded the increase of deaths between 2012 and 2021, and concluded an increase of 18% per million. Smoke inhalation injury is the most common cause of death in fire victims. Fire victims with both burns to their body and smoke inhalation injury have increased mortality rate and length of hospital stay compared to those with burns alone.

After recent fire exposure, some of the signs and symptoms of smoke inhalation injury include cough, wheezing, stridor, confusion, difficulty breathing, low oxygen saturation, smoke debris (especially on the face or in saliva), burns (especially on the face), singed facial or nose hairs, or hoarse voice. A careful history can be helpful in determining where the fire occurred and what chemical fumes could have been inhaled as a result to determine what systemic toxicities may be present.

Smoke inhalation injury can lead to minor or major respiratory complications. Acute respiratory distress syndrome (ARDS) is a relatively delayed complication of smoke inhalation injury caused by chemical fumes inducing an inflammatory response in lung tissue, especially the small air sacs in the lungs where critical gas exchange occurs. Another potential complication is swelling of the upper airway from heat and chemical damage, which can become profound enough to obstruct breathing. The onset of airway swelling can be relatively delayed, making it difficult to intubate later on. Endotracheal intubation is considered early in certain situations for this reason. Other possible complications include pneumonia, vocal cord dysfunction and damage, and tracheal stenosis (usually delayed).