Somerville House is an independent, boarding and day school for girls, located in South Brisbane, an inner-city suburb of Brisbane, Queensland, Australia.

Established in 1899 as the Brisbane High School for Girls, the School was eventually named after the Scottish scientific writer, Mary Somerville (1780–1872), though the school's official name is still Brisbane High School for Girls. Today, Somerville House is owned by the Presbyterian and Methodist Schools Association (PMSA), and provides classes from Preparatory to Year 12, within two sub-schools — Junior School (Years Prep to 6) and Senior School (Years 7 to 12). Within the Senior School it is also split into Middle Years (Years 7–9) and Senior Years (Years 10–12). The school currently caters for approximately 1,385 students from Prep to Year 12, including approximately 100 boarders currently ranging from Years 6 to 12.

Somerville House is affiliated with the Association of Heads of Independent Schools of Australia (AHISA), the Junior School Heads Association of Australia (JSHAA), the Alliance of Girls' Schools Australasia (AGSA), the Australian Boarding Schools Association (ABSA), and is a founding member of the Queensland Girls' Secondary Schools Sports Association Inc (QGSSSA).

The boarding house, Cumbooquepa, meaning waterholes that existed below the house, is listed on the Queensland Heritage Register.

The Brisbane High School for Girls (later to be known as Somerville House) was established with 39 students in the basement of the Baptist City Tabernacle at 183 Wickham Terrace, by Eliza Fewings in October 1899. The early school consisted of a large Assembly hall, drill hall, and a number of separate classrooms, with the four founding boarders living with Fewings at her home, "Glen Olive", in Toowong. Fewings, who had previously been Headmistress of the Brisbane Girls Grammar School, but after being dismissed, decided to open her own school, she aimed to create a school community where girls could be educated and equipped with social graces, and would be able to take a leading role in the management of the nation. Based on English models, within three years it became the largest girls' secondary school in Queensland, with 150 students.

In 1900, the boarders moved to "Whytecliffe" at Albion, a property which still stands in Whytecliffe Street. In July 1903, the boarders were moved again, this time to "Garth House" on Wickham Terrace, which was closer to the Day School. Early in 1906, after Miss Fewings returned from a trip abroad, the boarding students were relocated once more to "Cheltenham", which was situated in what is now Jephson Street, Toowong.

Constance Elizabeth Harker had been an acting headteacher and she and Marjorie Jarrett purchased the school in 1909, and so began their partnership as co-principals. The two women had met while teaching at the Presbyterian Ladies' College, Sydney, where Harker was senior English and classics mistress. Following their purchase of the school, they searched for a site in Brisbane that could house the day and boarding schools under one roof, and in 1912, settled on "Erneton" on Wickham Terrace, which was located next door to the boarders previous residence, "Garth House". A paddock at the rear of Garth House was rented for a netball court. As time went on, space became limited at the new site, and so Athol Place, a few doors away on the Terrace was rented for extra boarders and two primary classes.

Harker and Jarrett gained little income from the school, as teacher-proprietors had little chance of financing a modern expanding school, especially one with boarding facilities. In 1918, due to these financial struggles, they transferred ownership to the newly formed Presbyterian and Methodist Schools Association, while retaining their Principalship. In 1920 the school moved from Wickham Terrace to its present site on Mater Hill, in South Brisbane, opening with an enrolment of 225 pupils. The boarding-school occupied "Cumbooquepa",the now heritage-listed former home of prominent Brisbane businessman, newspaper publisher, and one time Mayor of Brisbane, Thomas Blacket Stephens and his son William Stephens mayor of the South Brisbane City Council (built 1890). A new classroom block was constructed in 1919, designed by architect Lange Powell. At this time the school's name was changed to Somerville House, in recognition of the work of Mary Somerville (1780–1872), a famous Scottish scientist and mathematician of the 19th century. Over the next two decades the school carried out a major building programme and established a good reputation.