SpaceX CRS-24, also known as SpX-24, was a Commercial Resupply Service mission to the International Space Station launched on 21 December 2021, at 10:07:08 UTC. The mission is contracted by NASA and is flown by SpaceX using a Cargo Dragon. This is the fourth flight for SpaceX under NASA's CRS Phase 2 contract awarded in January 2016.

SpaceX plans to reuse the Cargo Dragons up to five times. The Cargo Dragon is launched without SuperDraco abort engines, without seats, cockpit controls and the life support system required to sustain astronauts in space. The new Cargo Dragon capsules under the NASA CRS Phase 2 contract will land east of Florida in the Atlantic Ocean.

NASA contracted for the CRS-24 mission from SpaceX and therefore determines the primary payload, date of launch, and orbital parameters for the Cargo Dragon C209. (This effectively determined C209'a turnaround time, which broke the shortness record for reusable orbital spacecraft, at 164.3 days.) Two educational microcontrollers (Astro Pi and Calliope mini) are also being delivered as part of the payload of this mission.

SpaceX CRS-24 carries over 2,989 kg (6,590 lb) of science experiments, instruments, supplies, hardware, and Christmas presents up to the ISS and the crew of Expedition 66.

ANITA-2 is a trace gas monitoring system developed by OHB and SINTEF under contract of ESA.

A technology demonstration mission which consists of the following payloads:

A technology demonstration mission which consists of the microwave radiometers COWVR and TEMPEST.

The following research experiments will fly on SpaceX CRS-24: