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It was created by beverage expert Salvatore Calabrese, and named after the bar FIFTY in London, where Calabrese formerly worked before it closed.[10][11][12] It is described as sweet with a spicy finish that pairs well with Asian fusion cuisine.[10]
Salvatore Calabrese created the cocktail in 2004-2005 as his signature drink for the first menu of the bar FIFTY that opened in February 2005.[4][13] It is also said to have been created to commemorate his birthday.[14] Calabrese was influenced by Jean-George Vongerichten, a Michelin-starred chef, who made dishes where chili was a prominent ingredient.[4] This was during an era where vanilla-flavored vodkas were trendy.[4]
Variations include the MyZo cocktail (which uses lemon juice instead of lime juice and no honey syrup) and Fuego Manzana No.2 (which uses tequila instead of vodka and uses apple schnapps and apple juice instead of lime juice).[4]