St. James's Hall was a concert hall in London that opened on 25 March 1858, designed by architect and artist Owen Jones, who had decorated the interior of the Crystal Palace. It was situated between the Quadrant in Regent Street and Piccadilly, and Vine Street and George Court. There was a frontage on Regent Street, and another in Piccadilly. Taking the orchestra into account, the main hall had seating for slightly over 2,000 persons. It had a grand hall 140 feet (43 m) long and 60 feet (18 m) broad, the seating was distributed between ground floor, balcony, gallery and platform and it had excellent acoustics. On the ground floor were two smaller halls, one 60 feet (18 m) square; the other 60 feet (18 m) by 55 feet (17 m). The Hall was decorated in the 'Florentine' style, with features imitating the great Moorish Palace of the Alhambra. The Piccadilly facade was given a Gothic design, and the complex of two restaurants and three halls was hidden behind Nash's Quadrant. Sir George Henschel recalled its 'dear old, uncomfortable, long, narrow, green-upholstered benches (pale-green horse-hair) with the numbers of the seats tied over the straight backs with bright pink tape, like office files.'

The Hall was built jointly by two music publishing firms, Chappell & Co. and Cramer & Co., in the hope of attracting the growing audiences for fine musical performances that attended the Crystal Palace and the halls being built in the provinces. It stood empty for nearly a year after its opening. For almost half a century thereafter, the Hall was London's principal concert hall, to be succeeded by Queen's Hall in the 1900s and later by Wigmore Hall, the Royal Albert Hall and Royal Festival Hall. It became famous for its 'Monday Pops' concerts and Ballad Concerts, as the home of the Philharmonic Society and the Christy Minstrels and for the many famous conductors and performers who gave important performances there.

The first performance at the hall was The Hymn of Praise, sung by the Vocal Association, under Julius Benedict. Sims Reeves sang Beethoven's 'Adelaide' there (the first of many successes), accompanied by Arabella Goddard, in a concert at the end of May 1858. According to Reeves' biographer, 'The hall itself met with general approval, but the arrangements for chorus and orchestra were severely condemned.' In the same year, one of the first complete performances of J.S. Bach's St Matthew Passion to be heard in England was given there under William Sterndale Bennett, with Sims Reeves, Helen Lemmens-Sherrington, Charlotte Sainton-Dolby and Willoughby Weiss.

The hall became known for its continuous production of blackface minstrelsy from 1862 until 1904. Known as the Christy Minstrels and later the Moore and Burgess Minstrels, the Hall's resident minstrel troupe performed in one of the smaller halls located on the ground floor near the restaurant, below the main hall. Gilbert and Sullivan's 1893 comic opera, Utopia, Limited, contains a joke in which the Court of St. James's is purposely confused with St. James's Hall and its minstrel shows, and a parody of a minstrel number is included in the same scene.

In residence for the whole active life of the hall, the Minstrels had their permanent home there, but their interests often conflicted with those of the main hall. In January 1890, for instance, George Bernard Shaw wrote:

At the Hallé orchestral concert... I was inhumanly tormented by a quadrille band which the proprietors of St James's Hall (who really ought to be examined by two doctors) had stationed within earshot of the concert-hall. The heavy tum-tum of the basses throbbed obscurely against the rhythms of Spohr and Berlioz all the evening, like a toothache through a troubled dream; and occasionally, during a pianissimo, or in one of Lady Hallé's eloquent pauses, the cornet would burst into vulgar melody in a remote key, and set us all flinching, squirming, shuddering, and grimacing hideously.'

Only a fortnight later, the band, at first subdued, broke out in a 'wild strain of brazen minstrelsy' during the final bars of the funeral march in the Eroica Symphony. After the movement was applauded a member of the audience began calling out that a complaint should be lodged, and won general approval, hear, hear, and people standing up to look at him. On one occasion Lady Henschel and her daughter went to hear Joseph Joachim play at a Saturday 'Pop', but were so aware of the 'rhythmic gay sounds, thumping and shimmering away in a most enlivening manner', that they decided to go and hear Moore and Burgess instead.

Samuel Arthur Chappell, one of the brothers in the Chappell & Co. firm of Bond Street music publishers, who concentrated on selling brass and woodwind instruments, together with his brother Thomas, devised the idea of the Monday Popular Concerts, which established the fame and popularity of the hall. George Bernard Shaw reported that the concerts at the hall contributed greatly to the spread and enlightenment of musical taste in England. Monday 'Pops' were held in the evening, and Saturday 'Pops' on Saturday afternoons. These were chamber-concerts. Their programmes were almost exclusively 'classical', and consisted of piano and organ recital, singers, violinists, string quartets and other chamber ensemble. They were managed by John Boosey, and later by William Boosey, together with Chappell. In 1861 the Musical World observed: 'classical chamber music of the highest order is brought week after week within the reach of the shilling paying masses as it has now been no less than fifty-two times at St James's Hall.... swelling the total of the Monday Popular Concerts to no less than sixty-three within two years of their foundation.... Such a result is unparalleled in the history of musical entertainments.'