Stefania Casini (born 4 September 1948) is an Italian actress, screenwriter, director, and producer. She appeared alongside Robert De Niro and Gérard Depardieu in Bernardo Bertolucci's 1900 (1976) and received two David di Donatello Award nominations for her work in the 1983 film Lontano da dove. In recent years she was also the visual inspiration for the comics version of Frank Wedekind's LULU adapted by John Linton Roberson. She once posed for Playboy.

Currently she is a director of documentaries.

Casini studied Architecture at the Polytechnic. Casini is married to Giancarlo Soldi.