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Substituted naphthylethylamine
The substituted naphthylethylamines are a class of chemical compounds based on naphthalene. Many naphthylethylamines are naphthylaminopropanes (also known as naphthylisopropylamines) due to the presence of a methyl group at the alpha carbon of the alkyl chain. The naphthylethylamines are derivatives of the phenethylamines, while the naphthylaminopropanes are derivatives of the amphetamines.
There are two types of naphthylethylamines based on positional isomerism: 1-naphthylethylamines and 2-naphthylethylamines. Examples of these include 1-naphthylaminopropane (1-NAP) and 2-naphthylaminopropane (2-NAP), respectively.
The substituted napthylethylamines include the following compounds:
Additional naphthylethylamines include 4-NEMD, centanafadine (EB-1020), nafimidone, naphazoline, and xaliproden (SR-57746). Some synthetic cannabinoids such as THJ-018 and THJ-2201 are also naphthylethylamines.
Some related compounds that are not technically naphthylethylamines include 1-naphthylpiperazine and its derivatives like CSP-2503, F-11,461, S-14506, and S-14671. Another related compound is 2-naphthylpiperazine. DMNPC is a 2-naphthylpiperidine.
Many naphthylethylamines, like 2-naphthylaminopropane and derivatives, act as monoamine releasing agents (MRAs), monoamine reuptake inhibitors (MRIs), and/or monoamine receptor modulators. Naphthylpropylaminopentane (NPAP) is a monoaminergic activity enhancer (MAE). Some, such as 2-naphthylaminopropane and to a lesser extent 1-naphthylaminopropane, but not others, such as NPAP, are also variably potent monoamine oxidase inhibitors (MAOIs).
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Substituted naphthylethylamine
The substituted naphthylethylamines are a class of chemical compounds based on naphthalene. Many naphthylethylamines are naphthylaminopropanes (also known as naphthylisopropylamines) due to the presence of a methyl group at the alpha carbon of the alkyl chain. The naphthylethylamines are derivatives of the phenethylamines, while the naphthylaminopropanes are derivatives of the amphetamines.
There are two types of naphthylethylamines based on positional isomerism: 1-naphthylethylamines and 2-naphthylethylamines. Examples of these include 1-naphthylaminopropane (1-NAP) and 2-naphthylaminopropane (2-NAP), respectively.
The substituted napthylethylamines include the following compounds:
Additional naphthylethylamines include 4-NEMD, centanafadine (EB-1020), nafimidone, naphazoline, and xaliproden (SR-57746). Some synthetic cannabinoids such as THJ-018 and THJ-2201 are also naphthylethylamines.
Some related compounds that are not technically naphthylethylamines include 1-naphthylpiperazine and its derivatives like CSP-2503, F-11,461, S-14506, and S-14671. Another related compound is 2-naphthylpiperazine. DMNPC is a 2-naphthylpiperidine.
Many naphthylethylamines, like 2-naphthylaminopropane and derivatives, act as monoamine releasing agents (MRAs), monoamine reuptake inhibitors (MRIs), and/or monoamine receptor modulators. Naphthylpropylaminopentane (NPAP) is a monoaminergic activity enhancer (MAE). Some, such as 2-naphthylaminopropane and to a lesser extent 1-naphthylaminopropane, but not others, such as NPAP, are also variably potent monoamine oxidase inhibitors (MAOIs).