Super-Villain Team-Up is the name of two American comic book series published by Marvel Comics. Both series featured supervillains as the protagonists.

The first series started in 1975 with two giant-size issues before launching as a regular series, and was mostly bi-monthly during its existence. It initially teamed up Doctor Doom and the Sub-Mariner, who had lost his own series, from which it picked up the unresolved plots, especially that of the comatose Atlanteans. After a succession of writers and artists and a crossover with The Avengers, the plot gets resolved in issue #13 when Doctor Doom revives the Atlanteans, thus dissolving his alliance with the Sub-Mariner.

Issue #14 (Oct. 1977), which featured Magneto and Doctor Doom, was billed as the final issue of the series and its plotline was resolved in The Champions #16. The following year, SVTU continued with issue #15 (Nov. 1978), a reprint of Astonishing Tales #4–5. Issues #16 (May 1979) and #17 (June 1980) featured the Red Skull and the Hate-Monger. The irregular publishing frequency of the final three issues was due to a legal maneuver to prevent DC Comics from trademarking the term "super-villain".

The series saw the death of the Sub-Mariner's 1940s sweetheart Betty Dean and the death of her murderer, Doctor Dorcas. Steve Englehart created The Shroud, a character partly inspired by Batman, shortly before he started to work for DC Comics on Detective Comics.

In 2007 Marvel published Super-Villain Team-Up: MODOK's 11, a five-issue miniseries featuring 11 supervillains in the manner of the movie Ocean's Eleven.

This 2009 miniseries features Doctor Doom working with other villains.