The Supreme Court of Missouri (SCOMO) is the highest court in the state of Missouri. It was established in 1820 and is located at 207 West High Street in Jefferson City, Missouri. Missouri voters have approved changes in the state's constitution to give the Supreme Court exclusive jurisdiction – the sole legal power to hear – over five types of cases on appeal. Pursuant to Article V, Section 3 of the Missouri Constitution, these cases involve:

Unless their case involves one of those five issues, people who want a trial court's decision reviewed must appeal to the Missouri Court of Appeals. Most of these cases involve routine legal questions and end there. The Court of Appeals is divided geographically into the Eastern District, Western District and Southern District.

Certain cases, however, can be transferred to the Supreme Court – at the Court's discretion – if it determines that a question of general interest or importance is involved, that the laws should be re-examined, or that the lower court's decision conflicts with an earlier appellate decision. This is similar to the process the United States Supreme Court uses in accepting cases. In addition, the Court of Appeals may transfer a case to the Supreme Court after an opinion is issued, either upon application of one of the parties or at the request of one of the judges on the appellate panel.

Additionally the Supreme Court hears all impeachments of elective officers - except for governor or a member of the supreme court, for them a special commission is provided.

In addition to issuing legal decisions, the Supreme Court supervises the lower state courts with the assistance of the Office of State Courts Administrator ("OSCA"). OSCA oversees court programs, provides technical assistance, manages the budget of the state's judicial branch, and conducts educational programs. The Supreme Court also issues practice and procedure rules for Missouri court cases, including procedure and evidence rules. The Supreme Court licenses attorneys practicing in Missouri, and disciplines lawyers and judges for violating ethical rules.

Judges of the court are selected through the Missouri Nonpartisan Court Plan, nationally known as the Missouri Plan.

Under the plan, the Appellate Judicial Commission submits the names of three nominees to the governor. If the governor fails to make an appointment with 60 days of the nominees being named, the Commission shall make the appointment. Judges serving for at least a year are placed on the general election ballot for a retention vote of the people. If retained, judges serve a term of 12 years.

At the time of its establishment, the court had three judges, which was expanded to five in 1872, and seven in 1890.