Sym-Bionic Titan is an American animated television series created by Genndy Tartakovsky (in his fourth collaboration with the channel), Bryan Andrews and Paul Rudish for Cartoon Network. The series focuses on a trio consisting of the alien princess Ilana, the strict but rebellious alien soldier Lance, and the robot Octus, who arrive on Earth and combine themselves to create the titular Sym-Bionic Titan.

A preview of the series was first shown at the 2009 San Diego Comic-Con, and further details were revealed at Cartoon Network's 2010 upfront. The series premiered on September 17, 2010, and ended on April 9, 2011, with a total of 20 episodes as ordered by the channel; Tartakovsky had hoped to expand on that, but the series was not renewed for a second season, as it "did not have any toys connected to it".

While Sym-Bionic Titan has never been released to DVD in the United States, all 20 episodes were available for purchase on iTunes and the Microsoft Store. On October 7, 2012, reruns of the series began airing on Adult Swim's Toonami block along with the 2011 television series of ThunderCats until Cartoon Network wrote-off Sym-Bionic Titan for financial reasons in September 2014. The series was later released on Netflix in 2019, but was removed from the service in December 2020.

Billed as "an exciting hybrid of high school drama and giant robot battles", Sym-Bionic Titan features "the adventures of three beings from the planet Galaluna who crash-land on Earth while attempting to escape their war-torn world". The series follows the lives of Lance (voiced by Kevin Thoms), Ilana (voiced by Tara Strong) and Octus (voiced by Brian Posehn), two alien teenagers and a robot respectively in the form of humanoids living on Earth, an "identical" planet to Galaluna, while fleeing an evil general who has taken over their home planet with the help of monstrous creatures called Mutraddi.

Ilana is the kind princess of the Galalunan royal family, Lance is a dark-hearted but capable soldier and Octus is a bio-cybernetic robot created by Ilana's father to protect her: all three having to now pose as normal high school students to blend into everyday life in Sherman, Illinois so Lance and Octus can conceal Ilana from General Modula (Don Leslie) and his hideous space mutants sent to kill the sole heir of Galaluna and complete his conquest.

When called into battle, the Galalunans are outfitted with individual armor that provides more than ample protection. It is when the gravest of danger appears that Octus activates the sym-bionic defense program and he, Ilana, and Lance unite "Heart (Ilana), Body (Lance) and Mind (Octus)" and come together to form the spectacular cyber-giant, Sym-Bionic Titan.

Series co-creator Genndy Tartakovsky, best known for creating Dexter's Laboratory, Star Wars: Clone Wars and Samurai Jack for Cartoon Network, drew inspiration for the show from many sources. He grew up with various mecha anime series from the 1980s such as Robotech and Voltron: "For whatever reason, I have always loved the idea of kids driving giant robots". His biggest influence for the show were John Hughes films (such as Sixteen Candles and The Breakfast Club) and 1980s pop culture, while the relationship between the two teenage leads, Ilana and Lance, was inspired by that of Sheeta and Pazu, the two leads in Hayao Miyazaki's Castle in the Sky.

An episode of Samurai Jack with a similar plot, "Jack and the Flying Prince and Princess" (which had two aliens and a robot fleeing to seek help for their planet), may have also provided inspiration for the show. Tara Strong also voiced the princess in said episode.