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TAS2R16
TAS2R16 (taste receptor, type 2, member 16) is a bitter taste receptor and one of the 25 TAS2Rs. TAS2Rs are receptors that belong to the G-protein-coupled receptors (GPCRs) family. These receptors detect various bitter substances found in nature as agonists, and get stimulated. TAS2R16 receptor is mainly expressed within taste buds present on the surface of the tongue and palate epithelium. TAS2R16 is activated by bitter β-glucopyranosides (such as salicin)
T2R16, Taste receptor 2 member 16, BGLPT.
The receptor is encoded by the TAS2R16 human gene which located on the long (q) arm of chromosome 7 at position 31.1-31.3, 997 bases. This gene is specifically expressed by taste receptor cells of the tongue and palate epithelia. Different individuals may have variations in the TAS2R16 gene, which can influence their sensitivity or preference for certain bitter compounds.
TAS2R16 consists of 291 amino acids. Molecular weight: 33,986 (Da). The receptor has 7 transmembrane helices, 3 intracellular loops and 3 extracellular loops. there are some conserved residues (black) and residues for which mutagenesis data is available.
The function of TAS2R16 is to bind to specific bitter-tasting molecules present in various foods, plants, and potentially harmful substances. When binding to these molecules, TAS2R16 initiates a signaling cascade that leads to the transmission of signals to the brain, which results in the perception of bitterness. TAS2R16 specifically is believed to play a central role in determining human preference to eat or avoid such vegetables with bitter β-glucosides, important dietary choices that ultimately influence human health.
The signaling pathway includes two essential components of the well-established taste signal transduction cascade: phospholipase C isoform β2 (PLCβ2) and the ion channel known as transient receptor potential cation channel subfamily M member 5 (TRPM5). Ca2+-flux signaling assays are commonly used to measure the function of TAS2R16 and other GPCRs, so this measurement represents the key function of the receptor.
There are 13 known ligands for TAS2R16.
The most well-studied natural ligand of TAS2R16 is salicin. In previous researches which analyzed how this receptor binds and signals, 38 residues that may be involved in signal transduction and 13 residues that contribute to ligand-specific interactions, were found to be involved.
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TAS2R16
TAS2R16 (taste receptor, type 2, member 16) is a bitter taste receptor and one of the 25 TAS2Rs. TAS2Rs are receptors that belong to the G-protein-coupled receptors (GPCRs) family. These receptors detect various bitter substances found in nature as agonists, and get stimulated. TAS2R16 receptor is mainly expressed within taste buds present on the surface of the tongue and palate epithelium. TAS2R16 is activated by bitter β-glucopyranosides (such as salicin)
T2R16, Taste receptor 2 member 16, BGLPT.
The receptor is encoded by the TAS2R16 human gene which located on the long (q) arm of chromosome 7 at position 31.1-31.3, 997 bases. This gene is specifically expressed by taste receptor cells of the tongue and palate epithelia. Different individuals may have variations in the TAS2R16 gene, which can influence their sensitivity or preference for certain bitter compounds.
TAS2R16 consists of 291 amino acids. Molecular weight: 33,986 (Da). The receptor has 7 transmembrane helices, 3 intracellular loops and 3 extracellular loops. there are some conserved residues (black) and residues for which mutagenesis data is available.
The function of TAS2R16 is to bind to specific bitter-tasting molecules present in various foods, plants, and potentially harmful substances. When binding to these molecules, TAS2R16 initiates a signaling cascade that leads to the transmission of signals to the brain, which results in the perception of bitterness. TAS2R16 specifically is believed to play a central role in determining human preference to eat or avoid such vegetables with bitter β-glucosides, important dietary choices that ultimately influence human health.
The signaling pathway includes two essential components of the well-established taste signal transduction cascade: phospholipase C isoform β2 (PLCβ2) and the ion channel known as transient receptor potential cation channel subfamily M member 5 (TRPM5). Ca2+-flux signaling assays are commonly used to measure the function of TAS2R16 and other GPCRs, so this measurement represents the key function of the receptor.
There are 13 known ligands for TAS2R16.
The most well-studied natural ligand of TAS2R16 is salicin. In previous researches which analyzed how this receptor binds and signals, 38 residues that may be involved in signal transduction and 13 residues that contribute to ligand-specific interactions, were found to be involved.