The Tarantula is a fictional character name used by several characters, usually supervillains, appearing in American comic books published by Marvel Comics. Most of these characters are primarily depicted as wearing a red and blue suit with retractable blades.

The original version of Tarantula (Anton Rodriguez) was introduced in The Amazing Spider-Man #134 (July 1974). Writer Gerry Conway recalled how he created the character:

During the political upheavals in South America during the 1970s, there was a real sense that we, the United States, were somewhat culpable, both for supporting the repressive regimes that were in power, and in the case of Chile, actually assisting in the overthrow of the democratically elected government. So, in that environment, a character like the Tarantula was inherently political. But the real reason I wanted to write that particular story was something said by my good friend Don Glut, who was also writing for Marvel at the time. Don once asked, "Why aren't there international heroes from smaller countries, a third-world, or old-world Captain America, like say, Captain Serbo-Croatia?" We laughed, but I really liked that notion: Just because the United States came up with their guy, why stop there? Why stop with the larger countries, the superpowers?

Acting as a patriotic enforcer for the oppressive dictatorship of the fictional South American country of Delvadia (essentially a Delvadian equivalent to Captain America), his defining marks are his red stretch costume with a black tarantula on its chest and the poisonous spikes attached to his gloves and boots. The character was killed off in the early 1980s, but the Tarantula identity has been carried on by a series of successors (such as Luis Alvarez and Jacinda Rodriguez). A modern version of Tarantula (Maria Vasquez) is introduced in Heroes for Hire #1 (October 2006).

A character with the Tarantula name previously appeared in Ghost Rider #2 (April 1967) with no connection between this character and any of the other depictions.

Antonio "Anton" Miguel Rodriguez is the first character to use the Tarantula codename.

He was a revolutionary terrorist in the small fictional South American republic of Delvadia, and was expelled from his small organization after murdering a guard for no reason during a robbery. Anton then went over to the side of the repressive fascist-dictatorship government, where the Tarantula identity was created for him to serve as a government operative and his country's counterpart of a patriotic symbol. After alienating his masters, Anton embarks on a criminal career in the United States.

Anton is hired by the Brand Corporation to silence an informer, but is again thwarted by Spider-Man. The Brand Corporation then orders him to kill Spider-Man. In an attempt to bestow him with spider-powers, Anton is injected with a mutagenic serum and placed in an electrolyte bath. The Will o' the Wisp disrupts the mutagenic process, causing him to transform into a monstrous spider creature. Horrified and disgusted with what he has turned into, Anton leaps off the building, begging for the police officers gathered below to kill him. Hit by a hail of gunfire, Anton strikes the street below and dies.