Tetrachlorodinitroethane is a chlorinated nitroalkane produced by nitration of tetrachloroethylene with dinitrogen tetroxide or fuming nitric acid. It's a powerful lachrymatory agent and pulmonary agent that is six times more toxic than chloropicrin. Tetrachlorodinitroethane may be used as a fumigant.

Tetrachlorodinitroethane was discovered by Hermann Kolbe in 1869 by reacting tetrachloroethylene and dinitrogen tetroxide.