The Adventures of Luther Arkwright is a nine-issue comic book limited series written and drawn by Bryan Talbot in the period 1978–1989. The story is adult in tone, with many mythological, historical, and political references, and a little explicit sex.

In 2003 English writer Warren Ellis called Arkwright "probably the single most influential graphic novel to have come out of Britain to date... probably Anglophone comics' single most important experimental work". The series was nominated for eight Eagle Awards in 1988, winning four: Best New Comic, Favourite Character, and Best Comic Cover, with Talbot winning the award for Favourite Artist. In addition, the book was given the 1989 Mekon Award for "Best British Work" by the Society of Strip Illustration.

The character of Luther Arkwright owes something to the influence of Michael Moorcock's Jerry Cornelius stories, though Moorcock and Talbot agree that the similarities between the characters are limited.^{[citation needed]}

Arkwright made his first appearance in the mid-1970s in "The Papist Affair", a short strip for Brainstorm Comix where Arkwright teamed up with a group of cigar-chewing biker nuns to recover the sacred relics of "St. Adolf of Nuremberg" from "a buncha male chauvinist priests".

Luther Arkwright is a work of apocalyptic science fiction set in parallel universes. The eponymous hero has the unique talent of being able to move between universes purely by force of will, and is aided by Rose Wylde, a telepath whose many incarnations across the parallels can communicate with one another. Luther and Rose are agents of a parallel universe known as "zero-zero", whose stable position in the multiverse has allowed the development of a world at peace with itself and sufficiently high technology to monitor the parallels for signs of the malign influence of the "Disruptors".

Most of the action in the story is set in a parallel world where the English Civil War has been indefinitely prolonged by the actions of the Disruptors, who are also responsible for unleashing "Firefrost", a legendary artifact that is destabilizing the multiverse. Arkwright intervenes on the Royalist side to draw out the Disruptors and locate and destroy Firefrost. Along the way his unit is ambushed, and he is killed, only to return to life with his powers enhanced.

The storytelling of the early episodes is complex, with flashbacks to Arkwright's upbringing by the Disruptors, escape to the parallel of his birth, and early missions for zero-zero intermingling with the course of his mission in neo-Cromwellian England, with story-telling techniques and art styles shifting to match. The scenes of Arkwright's death and rebirth are particularly abstract and full of religious and mythological symbolism. The comic is unusual in being one of the few adventure stories where the readers and the protagonist both know from the beginning that he will die; only the event itself is not known.

The later parts of the story have a more straightforward, linear form. In the end, Arkwright, having completed his mission, renounces violence.