The University of Manchester is a public research university in Manchester, England. The main campus is south of Manchester City Centre on Oxford Road. The university is considered a red brick university, a product of the civic university movement of the late 19th century. The current University of Manchester was formed in 2004 following the merger of the University of Manchester Institute of Science and Technology (UMIST) and the Victoria University of Manchester. This followed a century of the two institutions working closely with one another.

UMIST had its origins in the Manchester Mechanics' Institution, which was founded in 1824. The present University of Manchester considers this date, which is also the date of foundation of the ancestor of the Royal School of Medicine and Surgery, one of the predecessor institutions of the Victoria University of Manchester, as its official foundation year. The founders of the Mechanics' Institution believed that all professions, to some extent, depended on science. As such, the institute taught working individuals branches of science relevant to their existing occupations, believing its practical application would encourage innovation and advancements within those fields. The Victoria University of Manchester was founded in 1851, as Owens College. Academic research undertaken by the university was published via the Manchester University Press from 1904.

Manchester is the third-largest university in the United Kingdom by total enrolment and receives over 92,000 undergraduate applications per year, making it the most popular university in the UK by volume of applications. The University of Manchester is a member of the Russell Group, the N8 Group, and the US-based Universities Research Association. Additionally, the university owns and operates major cultural assets such as the Manchester Museum, the Whitworth art gallery, the John Rylands Library, the Tabley House Collection and the Jodrell Bank Observatory – a UNESCO World Heritage Site. The university and its predecessor institutions have had 26 Nobel laureates amongst their past and present students and staff.

The University of Manchester traces its roots to the formation of the Mechanics' Institution (the distant forerunner of UMIST) in 1824, and its heritage is linked to Manchester's pride in being the world's first industrial city. The English chemist John Dalton, together with Manchester businessmen and industrialists, established the Mechanics' Institution to ensure that workers could learn the basic principles of science.

John Owens, a textile merchant, left a bequest of £96,942 in 1846 (around £5.6 million in 2005 prices) to found a college to educate men on non-sectarian lines. His trustees established Owens College in 1851 in a house on the corner of Quay Street and Byrom Street which had been the home of the philanthropist Richard Cobden, and subsequently housed Manchester County Court. The locomotive designer Charles Beyer became a governor of the college and was the largest single donor to the college extension fund, which raised the money to move to a new site and construct the main building now known as the John Owens building. He also campaigned and helped fund the engineering chair, the first applied science department in the north of England. His bequest to the college was the equivalent of £10 million in 1876, at a time when it was in great financial difficulty. Beyer funded the total cost of construction of the Beyer Building to house the biology and geology departments. His will also funded Engineering chairs and the Beyer Professor of Applied mathematics.

The university has a rich German heritage. The Owens College Extension Movement formed its plans after a tour of mainly German universities and polytechnics. A Manchester mill owner, Thomas Ashton, chairman of the extension movement, had studied at Heidelberg University. Sir Henry Roscoe also studied at Heidelberg under Robert Bunsen and they collaborated for many years on research projects. Roscoe promoted the German style of research-led teaching that became the role model for the red-brick universities. Charles Beyer studied at Dresden Academy Polytechnic. There were many Germans on the staff, including Carl Schorlemmer, Britain's first chair in organic chemistry, and Arthur Schuster, professor of physics. There was even a German church nearby (part of the current campus).

In 1873, Owens College moved to new premises on Oxford Road, Chorlton-on-Medlock, and from 1880 it was a constituent college of the federal Victoria University. This university was established and granted a royal charter in 1880, becoming England's first civic university; following Liverpool and Leeds becoming independent, it was renamed the Victoria University of Manchester in 1903 and absorbed Owens College the following year.

By 1905, the two institutions were large and active forces. The Municipal College of Technology, forerunner of UMIST, was the Victoria University of Manchester's Faculty of Technology while continuing in parallel as a technical college offering advanced courses of study. Although UMIST achieved independent university status in 1955, the universities continued to work together. However, in the late-20th century, formal connections between the university and UMIST diminished and in 1994 most of the remaining institutional ties were severed as new legislation allowed UMIST to become a separate university with powers to award its own degrees. A decade later the development was reversed. The Victoria University of Manchester and the University of Manchester Institute of Science and Technology agreed to merge into a single institution in March 2003.