A theory is a systematic and rational form of abstract thinking about a phenomenon, or the conclusions derived from such thinking. It involves contemplative and logical reasoning, often supported by processes such as observation, experimentation, and research. Theories can be scientific, falling within the realm of empirical and testable knowledge, or they may belong to non-scientific disciplines, such as philosophy, art, or sociology. In some cases, theories may exist independently of any formal discipline.

In modern science, the term "theory" refers to scientific theories, a well-confirmed type of explanation of nature, made in a way consistent with the scientific method, and fulfilling the criteria required by modern science. Such theories are described in such a way that scientific tests should be able to provide empirical support for it, or empirical contradiction ("falsify") of it. Scientific theories are the most reliable, rigorous, and comprehensive form of scientific knowledge, in contrast to more common uses of the word "theory" that imply that something is unproven or speculative (which in formal terms is better characterized by the word hypothesis). Scientific theories are distinguished from hypotheses, which are individual empirically testable conjectures, and from scientific laws, which are descriptive accounts of the way nature behaves under certain conditions.

Theories guide the enterprise of finding facts rather than of reaching goals, and are neutral concerning alternatives among values. A theory can be a body of knowledge, which may or may not be associated with particular explanatory models. To theorize is to develop this body of knowledge.

The word theory or "in theory" is sometimes used outside of science to refer to something which the speaker did not experience or test before. In science, this same concept is referred to as a hypothesis, and the word "hypothetically" is used both inside and outside of science. In its usage outside of science, the word "theory" is very often contrasted to "practice" (from Greek praxis, πρᾶξις) a Greek term for doing, which is opposed to theory. A "classical example" of the distinction between "theoretical" and "practical" uses the discipline of medicine: medical theory involves trying to understand the causes and nature of health and sickness, while the practical side of medicine is trying to make people healthy. These two things are related but can be independent, because it is possible to research health and sickness without curing specific patients, and it is possible to cure a patient without knowing how the cure worked.

The English word theory derives from a technical term in philosophy in Ancient Greek. As an everyday word, theoria, θεωρία, meant "looking at, viewing, beholding", but in more technical contexts it came to refer to contemplative or speculative understandings of natural things, such as those of natural philosophers, as opposed to more practical ways of knowing things, like that of skilled orators or artisans. English-speakers have used the word theory since at least the late 16th century. Modern uses of the word theory derive from the original definition, but have taken on new shades of meaning, still based on the idea of a theory as a thoughtful and rational explanation of the general nature of things.

Although it has more mundane meanings in Greek, the word θεωρία apparently developed special uses early in the recorded history of the Greek language. In the book From Religion to Philosophy, Francis Cornford suggests that the Orphics used the word theoria to mean "passionate sympathetic contemplation". Pythagoras changed the word to mean "the passionless contemplation of rational, unchanging truth" of mathematical knowledge, because he considered this intellectual pursuit the way to reach the highest plane of existence. Pythagoras emphasized subduing emotions and bodily desires to help the intellect function at the higher plane of theory. Thus, it was Pythagoras who gave the word theory the specific meaning that led to the classical and modern concept of a distinction between theory (as uninvolved, neutral thinking) and practice.

Aristotle's terminology, as already mentioned, contrasts theory with praxis or practice, and this contrast exists till today. For Aristotle, both practice and theory involve thinking, but the aims are different. Theoretical contemplation considers things humans do not move or change, such as nature, so it has no human aim apart from itself and the knowledge it helps create. On the other hand, praxis involves thinking, but always with an aim to desired actions, whereby humans cause change or movement themselves for their own ends. Any human movement that involves no conscious choice and thinking could not be an example of praxis or doing.

Theories are analytical tools for understanding, explaining, and making predictions about a given subject matter. There are theories in many and varied fields of study, including the arts and sciences. A formal theory is syntactic in nature and is only meaningful when given a semantic component by applying it to some content (e.g., facts and relationships of the actual historical world as it is unfolding). Theories in various fields of study are often expressed in natural language, but can be constructed in such a way that their general form is identical to a theory as it is expressed in the formal language of mathematical logic. Theories may be expressed mathematically, symbolically, or in common language, but are generally expected to follow principles of rational thought or logic. In the social sciences, a new theory must explain the core relationships among units or process steps, exploring a current gap or unresolved debate in a field, extending its explanations into testable hypotheses and practical implications to benefit society.