Community hub
Recent from talks
Contribute something to knowledge base
Content stats: 0 posts, 0 articles, 1 media, 0 notes
Members stats: 0 subscribers, 0 contributors, 0 moderators, 0 supporters
Subscribers
Supporters
Contributors
Moderators
Thiethylperazine
Thiethylperazine (Torecan, Norzine) is an antiemetic of the phenothiazine class. It is an antagonist of dopamine receptors (DRD1, DRD2, DRD4) as well as of 5-HT2A, 5-HT2C receptors, mAChRs (1 through 5), α1 adrenergic receptor and H1 receptor.
Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice.
Thiethylperazine is highly lipofilic and it binds with membranes and serum proteins (over 85%). It accumulates in organs with high blood flow and penetrates the placenta. It cannot be removed with dialysis.
It is mainly metabolized in the liver and only 3% is eliminated unchanged. Thiethylperazine's half-life is 12 h.
In toxic doses above the terapeutic window, it increases the rate of cleft palate occurrence.
Theithylperazine may possess antipsychotic activity due to the antagonism of 5-HT2 and D2 receptors. It can cause extrapyramidal symptoms.[citation needed] Nevertheless, it was never marketed as an antipsychotic.
One cause of acute dystonia occurred in a 19-year-old male patient after discontinuation of this drug.
Signs of acute thiethylperazine overdose include extrapyramidal symptoms, confusion, convulsions, respiratory depression, and hypotension.
Thiethylperazine
Thiethylperazine (Torecan, Norzine) is an antiemetic of the phenothiazine class. It is an antagonist of dopamine receptors (DRD1, DRD2, DRD4) as well as of 5-HT2A, 5-HT2C receptors, mAChRs (1 through 5), α1 adrenergic receptor and H1 receptor.
Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice.
Thiethylperazine is highly lipofilic and it binds with membranes and serum proteins (over 85%). It accumulates in organs with high blood flow and penetrates the placenta. It cannot be removed with dialysis.
It is mainly metabolized in the liver and only 3% is eliminated unchanged. Thiethylperazine's half-life is 12 h.
In toxic doses above the terapeutic window, it increases the rate of cleft palate occurrence.
Theithylperazine may possess antipsychotic activity due to the antagonism of 5-HT2 and D2 receptors. It can cause extrapyramidal symptoms.[citation needed] Nevertheless, it was never marketed as an antipsychotic.
One cause of acute dystonia occurred in a 19-year-old male patient after discontinuation of this drug.
Signs of acute thiethylperazine overdose include extrapyramidal symptoms, confusion, convulsions, respiratory depression, and hypotension.
Recent media
Recent media