Toonstruck is a graphic adventure video game developed by Burst Studios, published by Virgin Interactive Entertainment and released in 1996 for DOS. The game uses hand-drawn imagery and animated characters, but the protagonist Drew Blanc (played by Christopher Lloyd) is represented as a video-captured live action character interacting with the cartoon world around him. In the game, Blanc is transported into the cartoon world he created while suffering from a creative block. Blanc is accompanied by his animated sidekick Flux Wildly.

Conceived in 1993 as a game geared towards children, Toonstruck was later re-written to be more adult-oriented. Virgin Interactive invested huge amounts of money into the game, which ended up costing in excess of US$8 million. In addition to Lloyd, the cast includes several well-known actors and voice actors such as Dan Castellaneta, Tim Curry, David Ogden Stiers and Dom DeLuise. Toonstruck features scan-line compressed FMV that is composited with hand-drawn animated sequences produced by Burst, Nelvana and Rainbow Animation.

Toonstruck was well received by gaming critics, who mostly praised the quality of the animation and the design of the puzzles, but it was a financial disappointment for Virgin. It has since been included in several lists of the best adventure games of all time.

Toonstruck is a point-and-click adventure game where the player controls Drew Blanc, accompanied by his cartoon sidekick Flux. The game uses a "Bottomless Bag" as an inventory icon, and the mouse pointer, represented by an animated white-gloved hand, is context-sensitive, changing its icon depending on what it is rolled over. Dialogue options with characters are displayed as graphical icons that represent the topic of conversation. One of the standard icons is a cube of ice (for "breaking the ice" with a character); as dialogue options are exhausted, the cube melts into a puddle of water. According to Joystick, there are 52 original characters to interact with, as well as 80 puzzles to solve and 120 objects to retrieve.

The main objective of the game is to locate and collect several items to build a machine that has an opposite effect to that of the antagonist, Count Nefarious. These components are spread throughout the three kingdoms of Cutopia, Zanydu and the Malevolands. Many of the puzzles are based on object manipulation, although there are also some logic and arcade-style puzzles. For certain parts, the player must use the abilities of Flux as a cartoon character to advance. This is done by selecting Flux and using him much like an item.

Toonstruck presents a non-linear structure. Puzzles often require using objects from one location in the others; therefore, players must travel back-and-forth through the three lands throughout the first part of the game. The second part of Toonstruck sees Drew being imprisoned in Count Nefarious's castle; this section takes place entirely within the castle, and unlike the first, Flux is not present. Similarly to the LucasArts adventure games, it is not possible to die in the game, and there are no dead-ends that require the player to start over or load an earlier save file.

Animator Drew Blanc is the original creator of the Fluffy Fluffy Bun Bun Show, which has been a ten-year success for his company. In reality, the many cute talking rabbits that star in the show sicken him. His self-revered creation Flux Wildly, a wise-talking small purple character, has been denied the chance of starring in his own show. Drew's boss Sam Schmaltz sets him the task of designing more bunnies to co-star in the show by the next morning. However, the depressed animator nods off, suffering from acute artist's block. He wakes in the night to find his television switched on, announcing the Fluffy Fluffy Bun Bun Show. Drew is mysteriously drawn into the TV screen and transported to a cartoon world populated by his own creations, among many other cartoon characters. He befriends Flux Wildly and discovers that this fictional paradise is being ravaged by a ruthless new character named Count Nefarious with a weapon of evil called the Malevolator, a flying saucer which mutates the idyllic landscape and its inhabitants into dark and twisted counterparts.

Upon meeting with King Hugh, the king of Cutopia, Drew is given the task of hunting down and stopping Nefarious, thereby restoring peace and harmony to the land, in return for safe passage back to three-dimensional reality. Drew and Flux go on a scavenger hunt through the lands of Cutopia, Zanydu and the Malevolands to collect the parts needed to complete the Cutifier, a counter-weapon to Nefarious's Malevolator. After Nefarious's feline assistant Ms. Fortune informs him that Drew (referred to as an "alien") is working against him, the villain sends his henchmen after Drew and Flux, who find several ways to hide from the clumsy stooges. As Drew and Flux carry on with their quest, Nefarious continues his attacks on Cutopia, destroying Fluffy Fluffy Bun Bun's meadow; turning the kingdom's Carecrow, a friendly mannequin, into a creepy scarecrow; and turning Polly and Marge, a sheep and a cow who produce butter in a barn, into a dominatrix and a submissive in bondage.