The Transhumanist Party is a political party in the United States. The party's platform is based on the ideas and principles of transhumanist politics, e.g., human enhancement, human rights, science, life extension, and technological progress.

The Transhumanist Party was founded in 2014 by Zoltan Istvan. Istvan became the first political candidate to run for office under the banner of the Transhumanist Party when he announced his candidacy for President of the United States in the United States presidential election of 2016; he did not have ballot access in any state and received 95 write-in votes from two states. As part of his campaign Zoltan and a cadre of transhumanist activists and embedded journalists embarked on a four-month journey in the coffin-shaped Immortality Bus, which traveled on a winding cross-country route from San Francisco to Washington D.C. The Transhumanist Party has been featured or mentioned in many major media sites, including the National Review, Business Insider, Extreme Tech, Vice, Wired, The Telegraph, The Huffington Post, The Joe Rogan Experience, Heise Online, Gizmodo, and Reason. Political scientist Roland Benedikter said the formation of the Transhumanist Party in the USA was one of three reasons transhumanism entered into the mainstream in 2014, creating "a new level of public visibility and potential impact."

Following the end of the 2016 presidential election, after Zoltan's 2016 presidential campaign was completed, Gennady Stolyarov II became the Chairman of the party, and the organization was restructured. Under Chairman Stolyarov, the party adopted a new Constitution, which included three immutable Core Ideals in Article I, Section I.

New positions were founded, including Pavel Ilin became Secretary, Dinorah Delfin Director of Admissions and Public Relations, Arin Vahanian as Director of Marketing, Sean Singh as Director of Applied Innovation, Brent Reitze as Director of Publication, Franco Cortese as Director of Scholarship, and B.J. Murphy as Director of Social Media. Restructured advisor positions included Zoltan Istvan as Political and Media Advisor, Bill Andrews as Biotechnology Advisor, Jose Cordeiro as Technology Advisor, Newton Lee as Education and Media Advisor, Keith Comito as Crowdfunding Advisor, Aubrey de Grey as Anti-Aging Advisor, Rich Lee as Biohacking Advisor, Katie King as Media Advisor, Ira Pastor as Regeneration Advisor, Giovanni Santostasi as Regeneration Advisor, Elizabeth Parrish as Advocacy Advisor, and Paul Spiegel as Legal Advisor.

The U.S. Transhumanist Party held six Platform votes during January, February, March, May, June, and November 2017, on the basis of which 82 Platform planks were adopted. The U.S. Transhumanist Party holds votes of its members electronically and is the first political party in the United States to use ranked-preference voting method with instant runoffs in its internal ballots.

In May 2018 the New York Times reported the U.S. Transhumanist Party as having 880 members. On July 7, 2018, the U.S. Transhumanist Party reached 1,000 members and released a demographic analysis of its membership.[4] This analysis showed that 704 members, or 70.4%, were eligible to vote in the United States, whereas 296 or 29.6% were allied members.

The Transhumanist Party presidential primary attracted media attention from BioEdge and the Milwaukee Record. While some media outlets reported Zoltan Istvan was considering running again, ultimately he did not join the party's primary. After a protracted primary process with nine candidates, featuring numerous debates, Johannon Ben Zion was elected as the party's nominee. After winning the primary, Ben Zion gave his acceptance speech at RAAD Fest 2019 in Las Vegas. and filed with the FEC. Shortly thereafter, film producer, entrepreneur, and longevity organizer Charlie Kam became Ben Zion's running mate.

In October 2019 Ben Zion spoke to the DC Transhumanists meetup in Arlington, VA. In November he spoke at the Foresight Institute's Vision Weekend Event in San Francisco, and at Princeton University.