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U.S. Route 21

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U.S. Route 21

U.S. Route 21 or U.S. Highway 21 (US 21) is a north–south United States Numbered Highway, spanning 393 miles (632 km) from Hunting Island State Park, South Carolina, to Wytheville, Virginia. The route traverses three states, South Carolina, North Carolina, and Virginia. It connects southeastern cities, including Columbia, South Carolina, and Charlotte, North Carolina.

US 21 starts at Hunting Island State Park, bypasses Beaufort, South Carolina, and then heads north across the low country, paralleling Interstate 77 (I-77) through urban and rural areas before entering North Carolina. In North Carolina, US 21 frequently merges with and splits from I-77. The route enters Virginia, passing through hilly terrain before ending at the intersection of Interstate 81 (I-81) / U.S. Route 52 (US 52) in Wytheville.

Despite the "1" indicating that it is a major north–south highway, US 21 only travels through three states and is no longer a cross-country route, as many sections have been replaced by I-77 in Ohio and West Virginia. Historically, US 21 was longer before the Interstate Highway System was established. US 21 originally ran from Cleveland, Ohio, to Yemassee, South Carolina, it was later extended to Beaufort and Hunting Island State Park. Over time, its length was reduced, making it the second-shortest major north–south route after U.S. Route 91 (US 91).

US 21 serves as an alternative to the more heavily trafficked interstates in the area, particularly I-77, I-26, and I-95.

US 21 travels 233.2 miles (375.3 km) through the state. Beginning at Hunting Island State Park, US 21 travels west toward Beaufort, where it widens to four lanes. The route bypasses Beaufort to the south, going through Port Royal, Shell Point, and Burton. In the Beaufort area, US 21 passes by the entrances to Parris Island and Marine Corps Air Station Beaufort, the major Marine Corps installations in the area. North of Beaufort, US 21 continues as a four-lane divided highway and intersects with US 17. The route travels in a wrong-way concurrency with US 17 south for seven miles (11 km) before turning north toward Yemassee, where it becomes a rural two-lane road and intersects with US 17 Alternate. North of Yemassee, US 21 splits off and crosses I-95 at exit 42.

The two-lane route continues through rural portions of the state. US 21 goes through Smoaks and Branchville and bypasses Orangeburg. North of Orangeburg, US 21 runs roughly parallel to I-26 until Gaston where it conjoins US 321 and becomes an urban highway. US 21 passes through Cayce, West Columbia, and Columbia.

North of Columbia, US 21 splits from US 321, reverting to a rural two-lane road parallel to I-77. In York County, US 21 enters urban areas again, connecting Rock Hill and Fort Mill. Near the North Carolina state line, US 21 merges with I-77 near Carowinds, then enters North Carolina.

US 21 begins as a concurrency with I-77 in Charlotte, which it repeats three times within the state. Its first break with I-77 is along Statesville Avenue, then proceeding through Huntersville and Cornelius, however, because of its close proximity to I-77 and North Carolina Highway 115 (NC 115), it has no interchange with I-485 by itself. The second break with I-77 occurs at Mooresville, where US 21 travels through the city and then northwest into Statesville. After Statesville, US 21 travels northeast to Harmony and Brooks Crossroads, before merging back with I-77 near Jonesville. However, Jonesville and Elkin connect with US 21 Bus. through centers of both towns, as an alternate route paralleling I-77. North of Elkin, US 21 splits with I-77 for the last time and goes north to Sparta, passing the Blue Ridge Parkway after a major, curvy section. North of Sparta, at Twin Oaks, US 221 overlaps with US 21 before entering Virginia. US 21 travels 124.5 miles (200.4 km) through the western Piedmont of North Carolina, either combined with I-77 or as a two-lane rural road; from the South Carolina state line to Elkin, travelers can easily skip a majority of US 21 via I-77.

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