The first USS Noa (DD-343/APD-24) was a Clemson-class destroyer in the United States Navy following World War I. She was named for Midshipman Loveman Noa. At the beginning of World War II she was converted to a High-speed transport and redesignated APD-24.

Noa was built by the Norfolk Navy Yard, Portsmouth, Virginia. Authorized 6 October 1917, she was laid down 18 November 1918. She was launched on 28 June 1919, sponsored by Mrs. Albert Morehead, sister of Midshipman Loveman Noa; and commissioned 15 February 1921.

Following shakedown out of Virginia, Noa operated out of Charleston, South Carolina. Through May 1922, she participated in Atlantic Coast training maneuvers. In late May, she sailed for duty on the Asiatic Station, steaming via the Mediterranean and Aden and Ceylon. She reached Singapore 14 August and on 30 September, she arrived at her new home yard at Cavite, Philippine Islands. Through the summer of 1922, Noa remained active on the Asiatic station. She patrolled Chinese and Philippine waters and attempted to protect American interests during the Chinese Civil War, which was renewed in November 1922.

On 27 February 1927, the Noa arrived at Nanjing, China, relieving USS Simpson as the ship stationed there "to protect American lives and property." On 24 March 1927, with her sister ship, USS William B. Preston, and Royal Navy light cruiser HMS Emerald, she helped to rescue foreigners from Nanjing. The three ships used their main batteries to lay down a barrage of shrapnel and high explosive on Socony Hill, driving back hostile Chinese forces and also halting sniping along the Nanjing Bund and a sortie by Kuomintang gunboats. This allowed refugees to retreat down the hill to the safety of U.S. and British warships. Noa also participated in the periodic fleet exercises which were intended to keep crew and equipment at peak efficiency.

Upon return to the United States on 14 August 1929, Noa went into the Mare Island Navy Yard for overhaul before assignment to West Coast operations. Through the next five years, she operated out of San Diego as a unit of the Battle Fleet. During the fall and winter of 1929, Noa was called upon to assist in plane guard duties with carriers Langley (CV-1) and Saratoga (CV-3), off the California coast. She thus participated in the early development of U.S. carrier-group tactics. She also took part in the fleet exercises from 1930 to 1934. Noa served as cruise ship for Naval Reserve Officer Training Corps students from the University of California, Berkeley from 17 June to 8 July 1934. She then steamed for Philadelphia on 14 August 1934, decommissioned there on 11 November 1934, and was placed in reserve.

Noa recommissioned at Philadelphia on 1 April 1940 and was fitted with a seaplane which nested just forward of the after deckhouse, replacing the after torpedo tubes. At the same time, a boom for lifting the aircraft was stepped in place of the mainmast. She steamed for the Delaware Capes in May and conducted tests with an XSOC-1 seaplane piloted by Lt. G. L. Heap. The plane was hoisted onto the ocean for takeoff and then recovered by Noa while the ship was underway. Lt. Heap also made an emergency flight 15 May to transfer a sick man to the Naval Hospital at Philadelphia.

Such dramatic demonstrations convinced the Secretary of the Navy that destroyer-based scout planes had value, and on 27 May, he directed that six new destroyers of the soon-to-be-constructed Fletcher-class (DD 476–481) be fitted with catapults and handling equipment. Because of mechanical deficiencies in the hoisting gear, the program was cancelled early in 1943. The concept thus failed to mature as a combat technique, but the destroyer-observation seaplane team was to be revived under somewhat modified conditions during later amphibious operations.

Noa spent much of the next two years on experimental assignments and on midshipman training operations out of Annapolis, Maryland. She underwent availability at Boston Navy Yard the first week of December 1941 and then participated in Chesapeake Bay exercises through 27 December. Next, she steamed for Key West, Florida and participated in the shakedown of major fleet units in the Gulf of Mexico. After acting as a plane and screen guard for the carrier Hornet, she steamed for Hampton Roads. En route, a large wave carried away part of her bridge and she put in at Charleston, S.C. for emergency repairs.