Vampirella (/væmpɪˈrɛlə/) is a vampire superheroine created by Forrest J Ackerman and comic book artist Trina Robbins in Warren Publishing's black-and-white horror comics magazine Vampirella #1 (Sept. 1969), a sister publication of Creepy and Eerie.

Writer-editor Archie Goodwin later developed the character from horror-story hostesses, in which capacity she remained through issue #8 (Nov. 1970), to a horror-drama leading character. The magazine was published continuously until 1983, when Warren Publishing ceased operations and its assets were bought by Harris Publications. Vampirella comics, both new and reprints, have continued through various publishers into the 21st century.

Vampirella initially appeared in Warren Publishing's black-and-white horror-comics magazine Vampirella #1 (Sept. 1969), running to issue #112 (March 1983), plus a 1972 annual reprinting stories from the series, and a 1977 special with color reprints of José González stories. The title was a sister magazine of Warren's horror anthologies Creepy and Eerie. Like those magazines' respective mascots, Uncle Creepy and Cousin Eerie, Vampirella hosted horror stories, though unlike them, she would also star in her own story, which would headline each issue. Vampirella was initially edited by Bill Parente. It was later edited by Archie Goodwin (issues #7–12, 34–35), Billy Graham (#13–16), Bill DuBay (#21–50, 87–95, 101–102) and Louise Jones (#51–86).

According to comics historian Richard J. Arndt, "Forrest Ackerman created, or at least had a strong hand in creating, Vampirella and he clearly had a major influence in shaping the lighthearted bad-girl story style of this issue as well." Her costume and hair style were designed by comics artist Trina Robbins. The character's first story artist was Tom Sutton. Artist Frank Frazetta's first-issue cover was a substitute for the original cover by European artist Aslan.

José González became the character's primary artist starting with issue #12. Other artists who drew Vampirella during her magazine's original run included Gonzalo Mayo, Leopold Sanchez, Esteban Maroto, José Ortiz, Escolano, Rudy Nebres, Ramon Torrents, Pablo Marcos, Jimmy Janes, John Lakey, Val Lakey, and Louis Small Jr.

Backup features appearing in Vampirella included "Tomb of the Gods", "Pantha" and "Fleur". Vampirella herself also appeared in a story with fellow Warren characters Pantha and the Rook in Eerie #94–95, and with most of the Warren characters in a company crossover special in Eerie #130.

Upon Warren's bankruptcy shortly afterward, Harris Publications acquired the company assets at auction in August 1983, although legal murkiness and a 1999 lawsuit by Warren publisher James Warren resulted in his reacquisition of the rights to sister publications Creepy and Eerie. Harris Comics published Vampirella stories in various series and miniseries from 1991 to 2007, beginning with Vampirella #113 (1988), a one-issue continuation of the original series, containing Vampirella reprints and one unrelated new story. Harris subsequently published the all-reprint one-shot Vampirella vs. the Cult of Chaos, and the four-issue miniseries Vampirella: Morning in America (Sept. 1991 - April 1992) by writer Kurt Busiek and penciler Louis La Chance. Three ongoing series followed:

The three-issue miniseries Vampirella Lives (Dec. 1996 – Feb. 1997) featured writer Warren Ellis and penciler Conner.