The Vaucluse Mountains (French: Monts de Vaucluse) are a mountain range of the French Prealps located in the departement of Vaucluse, between the Luberon Massif and Mont Ventoux.

The highest peak is Signal de Saint-Pierre, which reaches the height of 1,256 metres (4,121 ft).

Oriented east-west, the Toulourenc river and the Jabron torrent border the mountain range to the north, to the south by the Calavon valley and beyond the Luberon, to the west and north-west by the Comtat Venaissin plain, and to the east it extends nearly all the way to the Durance.

The northern part constitutes the secondary range of Ventoux – the highest point of the massif with an altitude of 1,910 m (6,270 ft) – and of the Lure (1,825 m (5,988 ft)), separated by the plateau of Albion (1,393 m (4,570 ft)).

The eastern part is a plateau of medium altitude which fluctuates between 800 and 1,000 m (2,600 and 3,300 ft) and culminates at the signal of Saint-Pierre at 1,256 m (4,121 ft) above sea level.

The western part is made up of a secondary range that travels from the region of Sault to the plain. The altitude varies between 300 and 1,000 m (980 and 3,280 ft). West of Mont Ventoux, Les Dentelles de Montmirail (The Laces of Montmirail), which has an altitude of 722 m (2,369 ft), take their name from the shape obtained by the erosion of the rock.

The Luberon regional natural park extends to the southern part of the massif.

The massif is made up of Mesozoic limestone, often permeable. The water sinks into the rock, creating underground networks (karstic system), emerging at low points such as the Fontaine de Vaucluse.