Vitacura is a commune of Chile located in Santiago Province, Santiago Metropolitan Region. It is one of the most expensive and fashionable areas of Santiago. Inhabitants are primarily high income families. It belongs to the Northeastern zone of Santiago de Chile.

There is an abundance of elite private schools in Vitacura and Las Condes, including Saint George's College, Colegio Santa Úrsula, Alliance Francaise, Colegio La Maisonette, Colegio Tabancura, Colegio Los Andes, Colegio Sagrados Corazones de Manquehue and Colegio San Benito.

The Costanera Norte tollway connects Vitacura with the international airport and subway stations are located in the neighboring municipality of Las Condes.

Vitacura is the site of ECLAC headquarters, home to the European Southern Observatory (ESO) headquarters in Chile, and home to Santiago's most exclusive shopping street, Avenida Alonso de Córdova.

According to the 2017 census conducted by the National Statistics Institute, Vitacura covers an area of 28.3 km² (11 sq mi) and had a population of 85,384 inhabitants, comprising 38,402 men and 46,982 women. The commune is entirely urban. Between the 2002 and 2017 censuses, the population increased by 4.77 percent, representing an absolute growth of 3,885 residents.

As a commune, Vitacura is a third-level administrative division of Chile administered by a municipal council, headed by a mayor (alcalde, in Spanish) who is directly elected every four years. The mayor Camila Merino (Evópoli) has been in the position since 2021. The communal council has the following members:

Vitacura belongs to Electoral District No. 11 together with the communes of Lo Barnechea, Las Condes, La Reina and Peñalolén and to the VII Senatorial District (Santiago Metropolitan Region).

It is represented in the Chamber of Deputies of the National Congress for the period 2022-2026 by the following deputies: