WGUC (90.9 FM) is a listener-supported public radio station in Cincinnati, Ohio. It is owned by Cincinnati Public Radio and has a classical music format. WGUC broadcasts using HD Radio technology and plays jazz on WGUC-HD2 and adult album alternative on WGUC-HD3. WGUC has radio studios in the same building as PBS Network affiliate WCET Channel 48, the Crosley Telecommunications Center on Central Parkway in Cincinnati.

WGUC has an effective radiated power (ERP) of 18,500 watts. Its transmitter is on Symmes Street, near Interstate 71, in Cincinnati.

In the late 1950s, a group of Cincinnati-area residents launched a campaign for a radio station devoted to cultural and public affairs programming, particularly classical music. A committee of the Queen City Association sought to bring either a repeater of WOSU-AM-FM in Columbus or a standalone fine arts station to Cincinnati.

WGUC signed on the air on September 21, 1960; 65 years ago (1960-09-21). The station was originally licensed to the University of Cincinnati, at the time owned by the City of Cincinnati. WGUC broadcast mostly classical music and was a training ground for students interested in a career in broadcasting.

When National Public Radio was first formed in the early 1970s, WGUC interrupted its classical music in afternoon drive time to carry All Things Considered. However, when NPR began offering additional weekday programming in the 1980s, that created the need for an additional NPR outlet in Cincinnati, at which time 91.7 WVXU (then licensed to Xavier University) became an NPR member station.

While the two stations both carried some NPR programs, the two NPR daily flagship newsmagazines aired separately. WVXU carried Morning Edition, while WGUC continued airing All Things Considered. With both stations now under the same licensee, program duplication, sometimes a problem in markets with more than one public radio station, were eliminated. This means that WGUC broadcasts almost exclusively classical music, while WVXU carries news and information programming, including both Morning Edition and All Things Considered.

WGUC was one of the first stations in the nation to meet the Corporation for Public Broadcasting's qualification standards; a charter member of NPR; and a founder of another network, American Public Radio (now Public Radio International). WGUC also had one of the first NPR satellite uplinks, the first digital west-to-east transatlantic broadcast, and is the only U.S. public radio station with an ongoing program to commission new music.

In 1994, UC outsourced WGUC's operations to Cincinnati Classical Public Radio, a community-based nonprofit organization. UC retained the station's license until 2002, when it sold the license to Cincinnati Public Radio. When Cincinnati Public Radio purchased Xavier University's "X-Star Network" (a group of stations headed by WVXU-FM) in 2005, WGUC moved its National Public Radio news and talk programming, including All Things Considered, which had aired on WGUC since the 1970s, to WVXU. The only NPR-produced show still airing on WGUC is the youth classical performance program From the Top, while the news and information programming is heard on WVXU around the clock, except for a couple hours of specialty music programming late nights.