WXIX-TV (channel 19) is a television station licensed to Newport, Kentucky, United States, serving the Cincinnati metro as the market's Fox affiliate. It is owned by Gray Media alongside low-power Telemundo affiliate WBQC-LD (channel 25) and Dayton–licensed low-power independent station WZCD-LD (channel 30). The three stations share studios at 19 Broadcast Plaza on Seventh Street in the Queensgate neighborhood just west of downtown Cincinnati; WXIX-TV's transmitter is located in the South Fairmount neighborhood on the city's northwest side.

Though the construction permit for a fourth television station to serve Cincinnati—originally assigned channel 74—had been obtained by a Newport group in 1953, it took 15 years and two sales before the station was built on channel 19; its facilities have always been in Ohio. A successful independent station under U.S. Communications Corporation, Metromedia, and Malrite Communications Group before the creation of Fox in 1986, the station began producing a local newscast in 1993 and today airs local newscasts in many time slots.

On July 9, 1953, Tri-City Broadcasting Company, owner of WNOP (740 AM) in Newport, filed with the Federal Communications Commission (FCC) for a construction permit to build a television station on channel 74, which had been assigned to Newport. After Gordon Broadcasting, owner of Cincinnati radio station WSAI, dropped its application for the channel, Tri-City became unopposed, and a construction permit for WNOP-TV was granted on December 24, 1953. Jim Lang, the former Campbell County sheriff that controlled Tri-City, envisioned the studios being adjoined by an amusement complex, complete with glass-enclosed restaurant, indoor ice rink, and outdoor swimming pool.

With Lang noting the tribulations of other UHF television stations around the country, however, Tri-City opted not to build its station right away. In April 1956, Lang told a reporter for The Cincinnati Enquirer that it would only be a "matter of time" until channel 74 went on air. Some conversation around the construction permit emerged in late 1962, when Lang sold WNOP radio and the WNOP-TV construction permit to television actor Dean Miller in a deal that ultimately fell through; Tri-City had presented to the FCC a proposal to add a lower-power channel 3 station to Cincinnati (between channel 2 in Dayton and channel 3 in Louisville), which Miller also supported, though chances of approval were slim.

In early 1965, channel 74 was no closer to going on the air than it had been a decade prior, but a change in ownership would lead to the foundation being laid to start a new commercial television station in Greater Cincinnati. That March, Tri-City sold the WNOP-TV permit to Daniel H. Overmyer, who was seeking to build a chain of major-market UHF television stations, for $100,000. Two changes were nearly immediate after the purchase closed. On September 14, 1965, the call letters were changed to WSCO-TV; Overmyer's stations all bore the initials of family members, with the new designation representing his wife, Shirley Clark Overmyer. The FCC was in the process of overhauling the UHF table of allocations at the time, which—together with a rulemaking petition from Overmyer—resulted in the lower channel of 19 being substituted for 74 in 1966. Overmyer selected the Bald Knob tower site, negotiated to lease a studio facility on Eighth Street in the Queensgate neighborhood, and announced that the new station would be affiliated with the new Overmyer Network once it started. Civic leaders in Newport objected, to no avail, to the idea of the station leaving Northern Kentucky.

A launch date of February 1, 1967, was initially slated, but the station did not start on that date. Instead, in April, Overmyer reached a deal to sell 80 percent of his television station group to the American Viscose Corporation (AVC).

The FCC approved the purchase of the Overmyer stations by AVC (which organized its television holdings under the name U.S. Communications Corporation) in December 1967. The following May, the call letters changed one more time to WXIX-TV, representing the Roman numeral for 19; station manager Doug McLarty also cited possible confusion with WCPO-TV in changing the call sign. From the Overmyer-built transmitter facilities and a studio site within an office suite at 801 West Eighth Street in Cincinnati, WXIX-TV debuted on the afternoon of August 1, 1968. The site from which channel 19 went on air was not the one Overmyer had selected; channel 19 was then sued by that property's owners.

Cincinnati's first commercial independent station featured a schedule consisting primarily of movies, sports, and syndicated programs, though it also produced a local daytime children's program hosted by puppeteer Larry Smith. The next year, the station debuted "The Cool Ghoul", a host of Scream-In, channel 19's Saturday night science fiction and horror movie played by Dick VonHoene. By the start of 1970, an American Research Bureau study had determined WXIX-TV was the number-one UHF independent station in the United States and in the top ten of all independents, VHF or UHF, nationwide. In 1970, the station purchased a facility on Taconic Terrace in Woodlawn, Ohio, from the defunct K & S Films for use as a larger studio base.