The Venture Bros. is an American adult animated action comedy television series created by Jackson Publick and Doc Hammer for Cartoon Network's late night programming block Adult Swim. Following a pilot episode on February 16, 2003, the series premiered on August 7, 2004. The Venture Bros. was one of Adult Swim's longest-running original series in terms of years, with seven produced seasons over fifteen years of production.

Throughout its run, the series has received critical acclaim for its writing, characters, humor, animation and world building. It ended its run on October 7, 2018, with a total of 81 episodes over the course of seven seasons as well as four specials. On September 7, 2020, series creator Jackson Publick announced on Twitter that the series had been canceled. A direct-to-video film, The Venture Bros.: Radiant Is the Blood of the Baboon Heart, was released on July 21, 2023, on digital and July 25, 2023, on Blu-ray and premiered on Adult Swim and Max 90 days later. The film serves as the series finale.

The series chronicles the lives and adventures of the Venture family: emotionally insecure, unethical and underachieving super-scientist father Dr. Thaddeus "Rusty" Venture; his well-meaning but dimwitted and incompetent teenage fraternal twin sons Hank and Dean Venture; the family's bodyguard, secret agent Brock Samson, or his temporary replacement, the reformed villain and pederast Sergeant Hatred; and the family's self-proclaimed archnemesis, The Monarch, a butterfly-themed supervillain. Initially conceived as a satire of boy adventurer and Space Age fiction prevalent in the early 1960s, it is considered to be an action/adventure series with both comedic, dramatic, and worldbuilding elements.

The characters of The Venture Bros. are largely re-imaginings of characters from Jonny Quest as well as comic book superheroes and supervillains.

Throughout the series, the Venture family has had various recurring antagonists. Many are current or former members of The Guild of Calamitous Intent, an organization founded to save mankind from self-destruction, but which now serves as an ad hoc placement agency matching super villains with appropriate heroic nemeses. The organization is run by the mysterious leader known only as "The Sovereign", who is revealed to be real-life rock star David Bowie in episode 26, though in episode 5 of the 5th season it is revealed that The Sovereign is actually a shape-shifter who frequently appears as Bowie.

Most episodes begin with a cold open and are shot to appear to be in letter-box format. Almost every episode features both a smash cut into the end credits, and a short scene following the credits. The second season of the series premiered on the internet via Adult Swim Fix on June 23, 2006, and on television on June 25, 2006; the season finished on October 15, 2006. The considerable delay between the end of the first season and the start of the second was partially caused by Adult Swim's delay in deciding whether to renew the show, primarily because the show is drawn and inked in the traditional animation style (albeit digitally), causing each episode to take considerable time to move through production. Additionally, the producers were dealing with the time constraints of producing a first-season DVD that contained live action interviews and commentary for several episodes.

The third season began on June 1, 2008, and marked the beginning of the show's broadcast in high-definition. A 15-minute rough cut of "The Doctor Is Sin" aired on April 1, 2008, as part of Adult Swim's April Fool's Day theme of airing sneak peeks of new episodes. The fourth season was split into two segments airing a year apart, with the first eight episodes airing in the fall of 2009 and the remaining episodes in fall of 2010. A note contained in the closing credits of the Season 4 finale indicated that the series would continue into the fifth season.

On February 6, 2013, it was announced that Season 5 would premiere on May 19, 2013. This was later shifted to June 2, 2013, at midnight.