The 1852 Whig National Convention was a presidential nominating convention held from June 16 to June 21, in Baltimore, Maryland. It nominated the Whig Party's candidates for president and vice president in the 1852 election. The convention selected General-in-Chief Winfield Scott (commanding the United States Army and led in the recent war with Mexico) for president and U.S. secretary of the navy William A. Graham for vice president.

In the aftermath of the Mexican–American War (1846–1848) and the Compromise of 1850, the Whig Party was torn over the issue of slavery. President Millard Fillmore, who had succeeded to the presidency in July 1850 after the death of Zachary Taylor, had the strong backing of Southern Whigs. However, his enforcement of the Fugitive Slave Act of 1850 had alienated many Northern Whigs, who supported either Scott or secretary of state Daniel Webster. Scott and Fillmore essentially tied on the first presidential ballot, while a smaller fraction of the vote went to Webster. There was little delegate movement over the next 46 ballots, but Scott gained momentum on the 48th ballot and clinched the nomination on the 53rd ballot.

Graham, Edward Bates of Missouri, and James Pearce of Maryland all won significant support on the first vice presidential ballot, but Graham clinched the nomination on the second ballot. In the general election, Scott and Graham were defeated by the Democratic candidates, Franklin Pierce and William R. King, who took office the following March 1853. This 1852 convention was the last Whig Party presidential convention to be held independent of other parties, as the 1856 Whig National Convention was held by a rump faction of Whigs and nominated the ticket previously selected by the competing 1856 American National Convention.

The congressional Whig caucus, led by Senator Willie P. Mangum, a supporter of Scott, met on April 9, 1852, to decide the date and location for the 1852 convention. The party chose to hold the convention in Baltimore, Maryland, at the Maryland Institute Hall, from June 16 to 21. The convention was temporarily chaired by George C. Evans and permanently chaired by John G. Chapman.

In late 1851 and early 1852, state conventions began to meet to select delegates to the national convention. The party was split between those who felt that Fillmore could not win the election and those who favored the president's nomination. Northern Whigs favored Scott while Southern Whigs tended to prefer Fillmore.

The party was also torn on the issue of slavery. Most in the party wanted to prevent slavery from becoming the dominating issue in the election. However, the Whigs were split on the issue of the Compromise of 1850, proposed and designed by Whig senator Henry Clay of Kentucky. President Zachary Taylor, a Southern Whig, had tried to avoid the issue altogether by proposing that California and New Mexico be admitted as free states immediately. After Taylor's death in July 1850, Fillmore, a moderate Whig, had supported Clay's compromise and was instrumental as president in its passage. Northern Whigs, led by William Henry Seward of New York, (a former governor and senator), adamantly opposed the compromise because it did not apply the Wilmot Proviso (which banned slavery in any federal territory acquired from Mexico after the Mexican–American War) to the western territories.

Northern Whigs launched an effort to associate Scott with the Free Soil wing of the party. Scott did not agree with the Free Soilers, who opposed the expansion of slavery into the western territories. Just days before the convention was scheduled to begin, Southern Whigs warned that they would not support Scott unless he pledged to disavow the Free Soilers and to exclude them from his administration if he was elected.

Encouraged by Fillmore's professed lack of desire to pursue the Whig nomination, Webster launched another campaign for the presidency in 1851. Fillmore was sympathetic to the ambitions of his secretary of state, but he was unwilling to completely rule out accepting the party's 1852 nomination, as he feared doing so would allow Seward to gain control of the party through Scott. Scott had supported the Compromise of 1850, but his association with Seward made him unacceptable to Southern Whigs. As Southerners retained a lingering distrust of Webster, they threw their backing behind Fillmore. Thus, Scott emerged as the preferred candidate of most Northern Whigs, Fillmore became the main candidate of Southern Whigs, and Webster was only able to win backing from a handful of delegates, most of whom were from New England.