2000 Soul Train Music Awards

• Prince

• Whitney Houston

• DMX

• Mary J. Blige

Winners are in bold text.

• R.Kelly – R.
  • Mary J Blige – Mary
  • DMX – Flesh of My Flesh, Blood of My Blood
  • TLC – Fanmail

• Ginuwine – 100% Ginuwine
  • Eric Benét – A Day in the Life
  • Donell Jones – Where I Wanna Be
  • Brian McKnight – Back at One

• Mary J. Blige – Mary
  • Macy Gray – On How Life Is
  • Whitney Houston – My Love Is Your Love
  • Jennifer Lopez – On the 6

• TLC – FanMail
  • Destiny's Child – The Writing's on the Wall
  • K-Ci & JoJo – It's Real
  • Les Nubians – Princesses Nubiennes

• Maxwell – "Fortunate"
  • Ginuwine – "So Anxious"
  • Donell Jones – "U Know What's Up"
  • Brian McKnight – "Back at One"

• Lauryn Hill – "Ex-Factor"
  • Mariah Carey (featuring Jay Z) – "Heartbreaker"
  • Whitney Houston – "My Love Is Your Love"
  • Chanté Moore – "Chanté's Got a Man"

• TLC – "No Scrubs"
  • Destiny's Child – "Bills, Bills, Bills"
  • Dru Hill – "Beauty"
  • Ideal – "Get Gone"

• Busta Rhymes (featuring Janet Jackson) – "What's It Gonna Be?!"
  • Missy Elliott (featuring Nas, Eve and Lil' Mo) – "Hot Boyz"
  • Q-Tip – "Vivrant Thing"
  • Will Smith – "Will 2K"

• Juvenile
  • Eve
  • Ideal
  • Angie Stone

• Dottie Peoples – God Can & God Will
  • Dorothy Norwood – The Lord is a Wonder
  • Richard Smallwood – Healing: Live in Detroit
  • Vickie Winans – Live in Detroit, Vol. 2

• Sisqo – "Thong Song"
• Destiny's Child - "Say My Name"
• Q-Tip
• Juvenile, Mannie Fresh, Lil Wayne and B.G.
• Mary J. Blige – "Your Child"
• Donell Jones and Lisa "Left Eye" Lopes – "U Know What's Up"
• Blaque
• Ginuwine – "So Anxious"
• Eric Benét and Tamia – "Spend My Life with You"
• DMX
• Lil' Kim