Sevilla came on fifth place in the domestic league with 68 points in total. Fourth-placed Osasuna also got 68 points, but won one more game. In the Copa del Rey, the team lost in the round of 16 against Cádiz. In the UEFA Cup, the team won their first ever European tournament by defeating Middlesbrough by 4–0 in the final.
 In (5 players)
| ||
|---|---|---|
| Player | From | Fee |
 Frédéric Kanouté
|
 Tottenham
|
€6.5M |
 Ivica Dragutinović
|
 Standard Liège
|
|
 Luis Fabiano
|
 Porto
|
|
 Enzo Maresca
|
Fiorentina
|
€2.5M |
 Andrés Palop
|
Valencia
|
|
| In (1 players)
| ||
|---|---|---|
| Player | From | Fee |
 Julien Escudé
|
 Ajax
|
€1.5M |
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
|
|
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
|---|---|---|---|---|---|---|---|---|---|---|
| 3 | Valencia | 38 | 19 | 12 | 7 | 58 | 33 | +25 | 69 | Qualification for the Champions League third qualifying round |
| 4 | Osasuna | 38 | 21 | 5 | 12 | 49 | 43 | +6 | 68 | |
| 5 | Sevilla | 38 | 20 | 8 | 10 | 54 | 39 | +15 | 68 | Qualification for the UEFA Cup first round |
| 6 | Celta Vigo | 38 | 20 | 4 | 14 | 45 | 33 | +12 | 64 | |
| 7 | Villarreal | 38 | 14 | 15 | 9 | 50 | 39 | +11 | 57 | Qualification for the Intertoto Cup third round |
| 4 January 2006 | Cádiz | 3–2 | Sevilla | Estadio Ramón de Carranza |
| 18:00 | Mirosavljević  25'Medina 27'Martí 59' (o.g.) |
Kanouté 70', 88' |
Attendance: 12,000 Referee: Bernardino González Vázquez |
| 11 January 2006 | Sevilla | 0–0 (2–3 agg.) | Cádiz | Ramón Sánchez Pizjuán Stadium, Seville |
| 18:00 |
| 15 September 2005 | Sevilla | 0–0 |  Mainz 05 | Ramón Sánchez Pizjuán Stadium, Seville |
| 21:30 | Report | Attendance: 34,160 Referee: Rob Styles |
| 29 September 2005 | Mainz 05 | 0–2 (0–2 agg.) | Sevilla | Commerzbank-Arena, Frankfurt |
| 20:30 | Report | Kanouté 9', 40' |
Attendance: 33,400 Referee: Matteo Trefoloni |
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification | SEV | ZEN | BOL | BJK | VIT | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sevilla
|
4 | 2 | 1 | 1 | 8 | 4 | +4 | 7 | Advance to knockout stage | — | — | — | 3–0 | 3–1 | |
| 2 |  Zenit Saint Petersburg
|
4 | 2 | 1 | 1 | 5 | 4 | +1 | 7 | 2–1 | — | — | — | 2–1 | ||
| 3 | Bolton Wanderers
|
4 | 1 | 3 | 0 | 4 | 3 | +1 | 6 | 1–1 | 1–0 | — | — | — | ||
| 4 |  Beşiktaş
|
4 | 1 | 2 | 1 | 5 | 6 | −1 | 5 | — | 1–1 | 1–1 | — | — | ||
| 5 | Vitória de Guimarães
|
4 | 0 | 1 | 3 | 4 | 9 | −5 | 1 | — | — | 1–1 | 1–3 | — |
| 3 November 2005 | Sevilla | 3–0 | Beşiktaş | Ramón Sánchez Pizjuán Stadium, Seville |
| 21:30 | Saviola 64' Kanouté 65', 89' |
Report | Attendance: 27,862 Referee: Johan Verbist |
| 24 November 2005 | Zenit Saint Petersburg | 2–1 | Sevilla | Petrovsky Stadium, Saint Petersburg |
| 18:30 | Kerzhakov 11', 88' |
Report | Saviola 90+3' (pen.) |
Attendance: 12,500 Referee: Philippe Leuba |
| 1 December 2005 | Sevilla | 3–1 | Vitória de Guimarães | Ramón Sánchez Pizjuán Stadium, Seville |
| 21:30 | Saviola 10', 28' Adriano 39' |
Report | Benachour 44' |
Attendance: 30,306 Referee: Paolo Bertini |
| 14 December 2005 | Bolton Wanderers | 1–1 | Sevilla | Reebok Stadium, Bolton |
| 20:45 | Ngotty 66' |
Report | Adriano 74' |
Attendance: 15,623 Referee: Michael Weiner |
| 15 February 2006 | Lokomotiv Moscow | 0–1 | Sevilla | Lokomotiv Stadium, Moscow |
| 17:30 | Report | López 75' |
Attendance: 10,223 Referee: Steve Bennett |
| 23 February 2006 | Sevilla | 2–0 (3–0 agg.) | Lokomotiv Moscow | Ramón Sánchez Pizjuán Stadium, Seville |
| 21:30 | Maresca 34' Puerta 90' |
Report | Attendance: 19,970 Referee: Alain Sars |
| 9 March 2006 | Lille | 1–0 | Sevilla | Stadium Nord Lille Métropole, Lille |
| 19:00 | Dernis 24' |
Report | Attendance: 11,009 Referee: Wolfgang Stark |
| 15 March 2006 | Sevilla | 2–0 (2–1 agg.) | Lille | Ramón Sánchez Pizjuán Stadium, Seville |
| 21:00 | Kanouté 29' Luís Fabiano 45+2' |
Report | Attendance: 33,660 Referee: Mike Riley |
| 30 March 2006 | Sevilla | 4–1 | Zenit St Petersburg | Ramón Sánchez Pizjuán Stadium, Seville |
| 21:00 | Saviola 14', 80' Martí 56' (pen.)Adriano 90+3' |
Report | Kerzhakov 45' |
Attendance: 28,633 Referee: Alain Hamer |
| 6 April 2006 | Zenit Saint Petersburg | 1–1 (2–5 agg.) | Sevilla | Petrovsky Stadium, Saint Petersburg |
| 18:00 | Hyun 50' |
Report | Kepa 66' |
Attendance: 17,028 Referee: Stefano Farina |
| 20 April 2006 | Schalke 04 | 0–0 | Sevilla | Veltins-Arena, Gelsenkirchen |
| 20:30 | Report | Attendance: 53,551 Referee: Tom Henning Øvrebø |
| 27 April 2006 | Sevilla | 1–0 (a.e.t.) (1–0 agg.) | Schalke 04 | Ramón Sánchez Pizjuán Stadium, Seville |
| 21:30 | Puerta 101' |
Report | Attendance: 39,475 Referee: Massimo De Santis |
| 10 May 2006 | Middlesbrough | 0–4 | Sevilla | Philips Stadion, Eindhoven |
| 20:45 UTC+2 | Report | Luís Fabiano 27' Maresca 78', 84'Kanouté 89' |
Attendance: 32,100 Referee: Herbert Fandel |
