The 2012 Italian Grand Prix (formally known as the Formula 1 Gran Premio Santander d'Italia 2012) was a Formula One motor race that took place at the Autodromo Nazionale di Monza in Monza, Italy on 9 September 2012. It was the thirteenth race of the 2012 season, and the final race in Europe before the teams returned to Asia for the Singapore Grand Prix.

Lewis Hamilton qualified on pole, ahead of teammate Jenson Button. The result gave McLaren their sixty-second front-row lock-out, breaking the previous record set by Williams. Hamilton won the race by four seconds from Sergio Pérez, with Fernando Alonso completing the podium.

This was McLaren's last win at Monza until 2021 and as well the last race without Romain Grosjean until 2020 Sakhir Grand Prix. This was also the last F1 race for Jerome d'Ambrosio.

Tyre supplier Pirelli brought its silver-banded hard compound tyre as the harder "prime" tyre and the white-banded medium compound tyre as the softer "option" tyre.

The drag reduction system zones used in 2011 were shortened for the 2012 race. The first DRS zone, located on the straight between the second Lesmo corner and the Variante Ascari, was shortened by fifty meters, while the DRS zone on the front straight was shortened by five meters.

Lotus driver Romain Grosjean did not participate in the race due to receiving a one-race ban for his involvement in the first-lap incident at the Belgian Grand Prix that saw four cars crash heavily at the La Source hairpin. Grosjean was replaced by the team's testing and reserve driver, Jérôme d'Ambrosio. Estonian Kevin Korjus became reserve driver for the weekend.

Pastor Maldonado received two five-place grid penalties. the first for jumping the start of the Belgian Grand Prix and the second for causing an avoidable accident with Timo Glock after Grosjean's accident.

Paul di Resta was also demoted five places for an unscheduled gearbox change on Saturday morning, his second gearbox penalty of the season.