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| 2021 Potchefstroom Open | |
|---|---|
| Date | 8–14 February |
| Edition | 2nd |
| Surface | Hard |
| Location | Potchefstroom, South Africa |
| Champions | |
| Singles | |
 Benjamin Bonzi | |
| Doubles | |
 Marc-Andrea Hüsler /  Zdeněk Kolář | |
The 2021 Potchefstroom Open was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Potchefstroom, South Africa between 8 and 14 February 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 IND
|
Prajnesh Gunneswaran | 130 | 1 |
| FRA
|
Benjamin Bonzi | 134 | 2 |
| SUI
|
Marc-Andrea Hüsler | 143 | 3 |
 GBR
|
Jay Clarke | 190 | 4 |
 CAN
|
Brayden Schnur | 208 | 5 |
 TUR
|
Cem İlkel | 214 | 6 |
| CAN
|
Peter Polansky | 220 | 7 |
 DOM
|
Roberto Cid Subervi | 222 | 8 |
The following players received wildcards into the singles main draw:
Robbie Arends Vaughn Hunter Khololwam MontsiThe following players received entry into the singles main draw using protected rankings:
The following players received entry from the qualifying draw:
Benjamin Bonzi def. Liam Broady 7–5, 6–4. Marc-Andrea Hüsler / Zdeněk Kolář def. Peter Polansky / Brayden Schnur 6–4, 2–6, [10–4].
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