The 2022 State of the Union Address was given by the 46th president of the United States, Joe Biden, on March 1, 2022, at 9:00 p.m. EST, in the chamber of the United States House of Representatives to the 117th United States Congress.

It was Biden's first State of the Union Address and his second speech to a joint session of the United States Congress. Presiding over this joint session was the House speaker, Nancy Pelosi, accompanied by Kamala Harris, the vice president, in her capacity as the president of the Senate.

Biden's speech was primarily focused on the Russian invasion of Ukraine, which began six days earlier, as well as his touting of major policy achievements and goals surrounding the COVID-19 pandemic, the economy, and social issues.

Referring to Russia's ongoing invasion of Ukrainian territory, Biden called for worldwide solidarity with the Ukrainian people. At one point all in attendance gave a standing ovation to the Ukrainian ambassador who was in attendance, with many lawmakers wearing or holding Ukrainian flags in support. The recent invasion prompted the White House to drastically alter the speech just days before as events unfolded in Ukraine. However, in a widely reported gaffe, Biden mistakenly referred to Ukrainians as the "Iranian people" while addressing Congress. Biden rebuked calls to defund the police, saying "the answer is not to defund the police. It's to fund the police". This drew criticism from some Black Lives Matter activists, including Democratic representative Cori Bush.

Biden used the opportunity to outline a four-point unity agenda that included Biden's emphasis on a cancer moonshot, care for veterans, tackling drug abuse, and addressing mental health.

The date of the address, March 1, was approximately one month later than usual; all State of the Union addresses since 1934 have occurred in either January or early February. Some observers in the media attributed the cause of the delay to the spread of the Omicron variant during the ongoing COVID-19 pandemic, along with the United States’ participation in the 2022 Winter Olympics. Additionally, Clare Foran and Kevin Liptak stated in an article published by CNN that the delay "would give Biden more time to try to accomplish some of his legislative goals before addressing Congress and the nation". Although the Constitution of the United States requires the president to give Congress information about the "State of the Union", it does not specify when or how frequently this must occur, only "from time to time".

GOP Representatives Marjorie Taylor Greene and Lauren Boebert disrupted Biden during his speech at one point, with both chanting the Trumpist political slogan "Build the wall". Boebert also criticized the American presence in Afghanistan by shouting "You put them in, 13 of them", in reference to the 13 service members who died in the 2021 Kabul airport attack. A number of lawmakers booed Representative Boebert in response to her interruption of the President.

Iowa governor Kim Reynolds gave the Republican response to the State of the Union address. She mentioned the withdrawal of United States troops from Afghanistan and the Russian invasion of Ukraine. She also criticized the president's approach to foreign policy as "too little, too late." Relating to domestic policy, she criticized high inflation rates. She also criticized mask mandates and Democrats' handling of the COVID-19 pandemic in the United States. She said that as Governor of Iowa, her state was the first to reopen schools. She also criticized Biden's border policy.