5-Methyl-MDA

5-Methyl-MDA, also known as 5-methyl-3,4-methylenedioxyamphetamine, is an entactogen and psychedelic designer drug of the amphetamine class. It is a ring-methylated homologue of MDA and a structural isomer of MDMA.

5-Methyl-MDA acts as a selective serotonin releasing agent (SSRA) with IC₅₀ values of 107nM, 11,600nM, and 1,494nM for serotonin, dopamine, and norepinephrine release, respectively.

2-methyl-MDA and 5-methyl-MDA have been used to help guide computer modelling of the serotonin transporter complex.

5-Methyl-MDA is not scheduled by the United Nations' Convention on Psychotropic Substances.

5-Methyl-MDA is not explicitly scheduled at the federal level in the United States, however 5-Methyl-MDA is a structural isomer of MDMA, and so sales or possession could potentially be prosecuted under the Federal Analogue Act.

As per the Safe Streets and Communities Act, 5-Methyl-MDA, along with all other amphetamines, is a Schedule I controlled substance under the Controlled Drugs and Substances Act.