APOEL FC (Greek: ΑΠΟΕΛ; short for Αθλητικός Ποδοσφαιρικός Όμιλος Ελλήνων Λευκωσίας, Athletikos Podosferikos Omilos Ellinon Lefkosias, lit. "Athletic Football Club of Greeks of Nicosia") is a Cypriot professional football club based in Nicosia, Cyprus. APOEL is the most successful football team in Cyprus with an overall tally of 29 national championships, 21 cups, and 13 super cups.

APOEL's greatest moment in European competition occurred in the 2011–12 season, when they advanced out of the group stage of the UEFA Champions League (winning a group that included FC Porto, Shakhtar Donetsk, and Zenit St. Petersburg), then eliminated Olympique Lyonnais in the last 16, to become the first Cypriot team to reach the quarter-finals of the Champions League. APOEL's European competitions highlights also include appearances in the group stages of the 2009–10 and 2014–15 UEFA Champions League and the group stages of the 2013–14, 2015–16, and 2016–17 UEFA Europa League. They marked their most successful UEFA Europa League campaign during the 2016–17 season, when they managed to top their group (along with Olympiacos, Young Boys, and Astana) and eliminated Athletic Bilbao in the round of 32, to reach the last 16 of the competition for the first time in their history. APOEL is the only Cypriot club who have reached the group stages (and the knockout stages) of both major UEFA competitions (UEFA Champions League and UEFA Europa League). In the 2016–17 season, APOEL drew an average home league attendance of 7,126 and their highest league attendance was 15,462. Both were the highest in the league.

APOEL FC is part of the APOEL multi-sport club, which was founded in 1926 and maintains departments for several sports including football, basketball, volleyball, futsal, table tennis, bowling, cycling, archery, swimming and water polo. APOEL is one of the founding members of the Cyprus Football Association and also an ordinary member of the European Club Association, an organization that replaced the previous G-14 which consists of major football clubs in Europe.

The club was formed as POEL (Greek: ΠΟΕΛ; Ποδοσφαιρικός Όμιλος Ελλήνων Λευκωσίας, Podosferikos Omilos Ellinon Lefkosias, Football Club of Greeks of Nicosia) on 8 November 1926. The club's formation came about when a group of forty people, with a common vision, met and set the foundations for creating a football club that would represent the Greek residents of the capital and express their deep desire for Cyprus' incorporation (enosis) into Greece. The meeting took place at a traditional confectionery, owned by Charalambos Hadjioannou, downtown in Ledra Street and the first president of the club was Giorgos Poulias. The first clubhouse was the "Athenians Club" (Λέσχη Αθηναίων) at the end of Ledra Street.

After a journey to the football club in Alexandria, Egypt in 1927 the General Assembly of 1928 decided the players showed that they were not just good footballers but also excellent track and field athletes. Hence it was decided to create a track and field team in addition to the football team. The name APOEL was adopted to reflect this, with the 'A' standing for 'Athletic'. Soon after a volleyball team and a table tennis team were established.

Cyprus did not have any country-wide league until 1932. Football clubs of the time played friendly matches only. In 1932, Pezoporikos Larnaca organised an unofficial league, the first island-wide league, and it was won by APOEL after defeating AEL Limassol in the final by 4–0. In 1934, there was a disagreement between Trust and Anorthosis Famagusta on the organisation of the fourth unofficial league. APOEL and AEL Limassol organised a meeting for the foundation of a country-wide governing body and an official country-wide league. The meeting took place in APOEL's clubhouse on 23 September and the establishment of the Cyprus Football Association was agreed. Two years later the APOEL football team celebrated its first championship title of the official Cyprus football league. APOEL also won the championship for the following four years, making this a very successful period for the club with 5 consecutive championships (1936–1940).

Politics, however, would soon spark conflict within the team. On 23 May 1948 the board of the club send a telegram to the Hellenic Association of Amateur Athletics (Greek: Σ.Ε.Γ.Α.Σ.), with the opportunity of the annual Panhellenic Track and Field Competition, which included wishes that "the rebellion" is finished. Several leftist club members perceived the telegram as a political comment on the Greek Civil War and they distanced themselves from the club. A few days later, on 4 June 1948, they founded AC Omonia, which until today is the archrival of APOEL and there has been a traditional animosity between the fans of the two teams.

More conflicts led to further struggles for APOEL. Athletes belonging to the club frequently participated in national clashes. During the 1955–59 national uprising against the British, many of APOEL's athletes and members of the club were active members of EOKA (the National Organisation of Cypriot Fighters), the most outstanding example being the club's track and field athlete Michalakis Karaolis who was hanged by the British colonial authorities. During this period the football team had their closest brush with relegation as most football players were actively taking part in the national struggle.