The sixth season of Ang Probinsyano, a Philippine action drama television series on ABS-CBN, premiered on September 24, 2018, on the network's Primetime Bida evening block and worldwide on The Filipino Channel and concluded on April 5, 2019, after a total of 140 episodes, and following the celebration of its third anniversary. The series stars Coco Martin as SPO2 Ricardo Dalisay, together with an ensemble cast.

The sixth season of Ang Probinsyano follows Cardo and Vendetta's continued struggle against Lucas Cabrera, now President of the Philippines and Renato Hipolito. After rescuing the incumbent President Oscar Hidalgo from an assassination plot intended to supplant him as president, Vendetta must now find a way to restore Hidalgo back to the Presidency.

Elsewhere, Vendetta will also have to deal with Don Emilio Syquia who has reemerged from hiding. Now going by the name Señor Gustavo Torralba, his newfound criminal empire enjoys the protection of the Cabrera administration through the auspices of Hipolito.

As Vendetta makes its way back to Manila, their path will cross with the arrival of the baglady and bureaucrat of the Cabrera administration, Lily Ann Cortez (Lorna Tolentino). Lily plans on making the conflict between Vendetta and the Cabrera Administration more direct and emerge with the spoils from whoever it is left standing.

Vendetta finally obtains the trust of Oscar Hidalgo (Rowell Santiago) following another assassination attempt on his life, which was timely prevented by Cardo (Coco Martin) and Vendetta with Hidalgo witnessing everything that transpired. Now aware of the true colors of his supposed political allies, Hidalgo resolves to regain the presidency which Lucas Cabrera (Edu Manzano) unlawfully stole from him.

After the unlawful arrest of General Borja (Jaime Fàbregas) before interrogating him to find Vendetta's whereabouts, they had a party along with Lucas and Brandon Cabrera (Mark Anthony Fernandez) at the PNP Headquarters and one of Lucas' allies Albert Hernandez (Franco Laurel) was chosen by Lucas to become his vice president as PNP Chief Alejandro Terante (Soliman Cruz) became angered due to Renato Hipolito's (John Arcilla) negative and sarcastic remarks.

Meanwhile, Lola Flora (Susan Roces) became more stressed since Konsehala Gina Magtanggol (Mitch Valdes) and her cohorts destroyed her eatery especially after hearing of what happened to her brother while being informed by Billy (John Medina).

With the Philippine Government worsening due to its corruption created by Lucas and his administration, Cardo informs Oscar that they need to make their move. Therefore, Jerome quickly informs Cardo about what happened to his grandfather after being informed by Billy that General Borja was not detained at Camp Crame but in a military camp where he was pummeled and tortured by Terante and his group and they were concealing their corruptive acts by blaming Vendetta. Oscar knows that their actions were illegal. Worried of endangering his family, Cardo decided to rescue his grandfather at their hands and informs them that Terante knows the location where General Borja has been illegally detained.