Cannons was a stately home in Little Stanmore, Middlesex, England. It was built by James Brydges, 1st Duke of Chandos, between 1713 and 1724 at a cost of £200,000 (equivalent to £37,960,000 today), replacing an earlier house on the site. Chandos' house was razed in 1747 and its contents dispersed.

The name "Cannons" is an obsolete spelling of "canons" and refers to the Augustinian canons of St Bartholomew's Hospital, London, which owned the estate before the English Reformation.

Cannons was the focus of the first Duke's artistic patronage – patronage which led to his nickname "The Apollo of the Arts". Brydges filled Cannons with Old Masters and Grand Tour acquisitions, and also appointed Handel as resident house composer from 1717 to 1718. Such was the fame of Cannons that members of the public flocked to visit the estate in great numbers and Alexander Pope was unjustly accused of having represented the house as "Timon's Villa" in his Epistle of Taste (1731).

The Cannons estate was acquired by Chandos in 1713 from the uncle of his first wife, Mary Lake. Mary's great-grandfather Sir Thomas Lake had acquired the manor of Great Stanmore in 1604. Following the first Duke's death in 1744, Cannons passed to his son Henry Brydges, 2nd Duke of Chandos. Due to the cost of building Cannons and significant losses to the family fortune in the South Sea Bubble there was little liquid capital in Henry's inheritance, so in 1747 he held a twelve-day demolition sale at Cannons which saw both the contents and the very structure of the house itself sold piecemeal leaving little more than a ruin barely thirty years after its inception. The subsequent villa built by William Hallett is now occupied by North London Collegiate School.

There is archaeological evidence the site was used in Roman times for brick and tile making.

In mediaeval times the site was a part of the endowment of the Priory of St Bartholomew's which operated St Bartholomew's Hospital in London. This gave it the name Cannons, canon was an archaic term for certain orders of monks including the Augustinians of St Bartholomew's Priory. At the Dissolution of the Monasteries the land was sold into private hands in 1543. A large house was built during the 16th and 17th centuries at one point owned by Thomas Lake, James I's Chancellor of the Exchequer.

James Brydges was an MP for Hereford who achieved the post of Paymaster General to the Forces. He retired in 1713 with a fortune of £600,000, worth £58,000,000 today, he had gained by speculation with the money in his care. Brydges had inherited Cannons from his first wife Mary who died in 1712. In 1713 he married his cousin Cassandra Willoughby and began to enlarge the house. Brydges took personal control of the project and it was the work of a string of architects and landscape gardeners, who changed as they fell into and out of favour. One builder was used throughout, Edward Strong the Elder who had a remarkable pedigree including being the main builder for both St Paul's Cathedral and Blenheim Palace. Brydges used the house as a setting for his patronage of the arts stocking it with paintings, sculpture and holding opera performances. It was completed by 1720.

Brydges was made Earl of Caernavon in 1714 and later became duke of Chandos. His fortunes were damaged by financial losses in the South Sea Bubble of 1720. However, when his wife died in 1735, he remarried a wealthy 43-year-old widow, Lady Lydia Davall, who had £40,000 to her name.