Changthang Wildlife Sanctuary (or the Changthang Cold Desert Wildlife Sanctuary), a high-altitude wildlife sanctuary in the Ladakhi adjunct of the Changthang plateau in Leh district of Indian Union Territory of Ladakh, is one of the 3 largest wildlife sanctuaries in Ladakh, others being Karakoram Wildlife Sanctuary and Hemis National Park. It is 125 km east from Leh city, the capital of Ladakh.

Covering an area of 4000 km², the Changthang Wildlife Sanctuary lies entirely within the northeast area of India-administered Ladakh. It's boundaries, defined by the Wildlife Institute of India (WII), are:

It is important as one of the few places in India with a population of the Kiang or Tibetan Wild Ass, as well as the rare Black-necked Crane.

Hanle and Nyoma are important habitations in the area.

Nearest civilian airport, Kushok Bakula Rimpochee Airport, is at Leh. Military airstrip are at Nyoma 74 km northwest and Fukche 24 km east.

Upshi-Nyoma-Hanle-Demchok Road, which branches off the NH3 at Upshi, runs through the Changthang Wildlife Sanctuary.

Hanle-Kaza-Tabo Road is being constructed by the BRO under the Indo-China Border Roads (ICBR) scheme. This road connects to and partially overlaps with the 125 km long Kiato-Karzok Road, from Kiato (near Kaza in Spiti Valley in Himachal Pradesh) through the Takling La Tunnel (5575 m) to Karzok (on shores of Tso Moriri), being constructed by the BRO as fourth alternative route to Ladakh.

Hanle-Zursar-Imis La Road was completed by December 2023.