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Chloride

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Chloride

The term chloride refers to a compound or molecule that contains either a chlorine anion (Cl), which is a negatively charged chlorine atom, or a non-charged chlorine atom covalently bonded to the rest of the molecule by a single bond (−Cl). The pronunciation of the word "chloride" is /ˈklɔːrd/.

Chloride salts such as sodium chloride are often soluble in water. It is an essential electrolyte located in all body fluids responsible for maintaining acid/base balance, transmitting nerve impulses and regulating liquid flow in and out of cells. Other examples of ionic chlorides include potassium chloride (KCl), calcium chloride (CaCl2), and ammonium chloride (NH4Cl). Examples of covalent chlorides include methyl chloride (CH3Cl), carbon tetrachloride (CCl4), sulfuryl chloride (SO2Cl2), and monochloramine (NH2Cl).

A chloride ion (diameter 167 pm) is much larger than a chlorine atom (diameter 99 pm). The chlorine atom's hold on the valence shell is weaker because the chloride anion has one more electron than it does. The ion is colorless and diamagnetic. In aqueous solution, it is highly soluble in most cases; however, for some chloride salts, such as silver chloride, lead(II) chloride, and mercury(I) chloride, they are only slightly soluble in water. In aqueous solution, chloride is bonded by the protic end of the water molecules.

Chloride can be oxidized but not reduced. The first oxidation, as employed in the chlor-alkali process, is conversion to chlorine gas. Chlorine can be further oxidized to other oxides and oxyanions including hypochlorite (ClO, the active ingredient in chlorine bleach), chlorine dioxide (ClO2), chlorate (ClO
3
), and perchlorate (ClO
4
).

In terms of its acid–base properties, chloride is a weak base as indicated by the negative value of the pKa of hydrochloric acid. Chloride can be protonated by strong acids, such as sulfuric acid:

Ionic chloride salts react with other salts to exchange anions. The presence of halide ions like chloride can be detected using silver nitrate. A solution containing chloride ions will produce a white silver chloride precipitate:

The concentration of chloride in an assay can be determined using a chloridometer, which detects silver ions once all chloride in the assay has precipitated via this reaction.

Chlorided silver electrodes are commonly used in ex vivo electrophysiology.

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